Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 578713..579315 Replicon chromosome
Accession NZ_FO704550
Organism Xenorhabdus doucetiae strain FRM16

Toxin (Protein)


Gene name higB Uniprot ID A0A068QN01
Locus tag XDD1_RS02840 Protein ID WP_045968495.1
Coordinates 578713..579024 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag XDD1_RS02845 Protein ID WP_045968497.1
Coordinates 579025..579315 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XDD1_RS02825 575384..576379 + 996 WP_045973307.1 gluconate operon transcriptional repressor GntR -
XDD1_RS02830 576636..577193 + 558 WP_045968491.1 gluconokinase -
XDD1_RS02835 577190..578527 + 1338 WP_045968493.1 gluconate transporter -
XDD1_RS02840 578713..579024 + 312 WP_045968495.1 toxin HigB-2 Toxin
XDD1_RS02845 579025..579315 + 291 WP_045968497.1 helix-turn-helix domain-containing protein Antitoxin
XDD1_RS02850 579537..580751 - 1215 WP_045968499.1 SGNH/GDSL hydrolase family protein -
XDD1_RS02855 580738..581874 - 1137 WP_045968502.1 DUF459 domain-containing protein -
XDD1_RS02860 581861..582550 - 690 Protein_539 MBOAT family protein -
XDD1_RS02865 582558..583595 - 1038 WP_045968390.1 IS630 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-88)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12349.36 Da        Isoelectric Point: 9.9915

>T284893 WP_045968495.1 NZ_FO704550:578713-579024 [Xenorhabdus doucetiae]
MLFIETKLFTDDVVQLLTDDEYREFQEFLAIRPEFGQVIPDTGGLRKIRWASYRTGKRGGVRIIYYYKLSDSQIRLLLIY
KKGIKDNLTEKEKKILRSLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10912.60 Da        Isoelectric Point: 8.8928

>AT284893 WP_045968497.1 NZ_FO704550:579025-579315 [Xenorhabdus doucetiae]
MDAKLFERLTESMTQMNEIIDGIREPSRETHVIAVQVKHIRQLTGLSQTGFAKLISVNVDTLRNWEQGRRQPTGPAKALL
RAIERDPEHVLLALQV

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A068QN01

Antitoxin

Source ID Structure

References