Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 5399282..5400072 Replicon chromosome
Accession NZ_CP128550
Organism Pseudomonas alloputida strain NMI5594_09

Toxin (Protein)


Gene name yhaV Uniprot ID Q88NE5
Locus tag LU693_RS25080 Protein ID WP_010952397.1
Coordinates 5399605..5400072 (+) Length 156 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID I7C311
Locus tag LU693_RS25075 Protein ID WP_014859917.1
Coordinates 5399282..5399608 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LU693_RS25055 (LU693_025055) 5394816..5395877 - 1062 WP_049587435.1 HlyD family secretion protein -
LU693_RS25060 (LU693_025060) 5395906..5397447 - 1542 WP_010952401.1 MFS transporter -
LU693_RS25065 (LU693_025065) 5397564..5398469 - 906 WP_010952400.1 LysR family transcriptional regulator -
LU693_RS25070 (LU693_025070) 5398743..5399189 + 447 WP_010952399.1 universal stress protein -
LU693_RS25075 (LU693_025075) 5399282..5399608 + 327 WP_014859917.1 type II toxin-antitoxin system PrlF family antitoxin Antitoxin
LU693_RS25080 (LU693_025080) 5399605..5400072 + 468 WP_010952397.1 type II toxin-antitoxin system YhaV family toxin Toxin
LU693_RS25085 (LU693_025085) 5400145..5401005 - 861 WP_010952396.1 HlyD family secretion protein -
LU693_RS25090 (LU693_025090) 5401016..5401216 - 201 WP_003251718.1 DUF1656 domain-containing protein -
LU693_RS25095 (LU693_025095) 5401206..5403383 - 2178 WP_003251716.1 FUSC family protein -
LU693_RS25100 (LU693_025100) 5403380..5404909 - 1530 WP_010952395.1 efflux transporter outer membrane subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(17-152)

Antitoxin

PrlF antitoxin

(8-106)


Sequences

Toxin        


Download         Length: 156 a.a.        Molecular weight: 17962.34 Da        Isoelectric Point: 9.7963

>T284876 WP_010952397.1 NZ_CP128550:5399605-5400072 [Pseudomonas alloputida]
MSDASRKPLVIHGWTVIAHPLFLAKLDALSAQVEAQRDKDPTGYTKRNTFKRLAAIRRLAFDVIPQDPTKPEYRQGATLG
GDHKHWFRAKFFQQYRLFFRYHTPSRIIVLAWINDESSKRAYESSDDAYKVFQKMLHSGNPPDDWDQLLQEAAAD

Download         Length: 468 bp

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 11919.40 Da        Isoelectric Point: 4.3722

>AT284876 WP_014859917.1 NZ_CP128550:5399282-5399608 [Pseudomonas alloputida]
MAATFDVESTLTDRYQTTVPETVRRALGLKKRDKIHYSIRPDGGVILTRAEATEDDPVLGKFLDFLAHDIATNPQRLQVV
DAGLIARLDKLVGDAEVDLDQPLSADDE

Download         Length: 327 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q88NE5

Antitoxin

Source ID Structure
AlphaFold DB I7C311

References