Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 5303395..5304185 Replicon chromosome
Accession NZ_CP128549
Organism Pseudomonas monteilii strain NMI985_06

Toxin (Protein)


Gene name yhaV Uniprot ID A0A3G2HLC0
Locus tag LU680_RS25075 Protein ID WP_016713503.1
Coordinates 5303718..5304185 (+) Length 156 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID A0A0P7D0H8
Locus tag LU680_RS25070 Protein ID WP_016713504.1
Coordinates 5303395..5303721 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LU680_RS25050 (LU680_25050) 5298931..5299992 - 1062 WP_016713508.1 HlyD family secretion protein -
LU680_RS25055 (LU680_25055) 5300021..5301562 - 1542 WP_016713507.1 MFS transporter -
LU680_RS25060 (LU680_25060) 5301679..5302584 - 906 WP_016713506.1 LysR family transcriptional regulator -
LU680_RS25065 (LU680_25065) 5302855..5303301 + 447 WP_016713505.1 universal stress protein -
LU680_RS25070 (LU680_25070) 5303395..5303721 + 327 WP_016713504.1 type II toxin-antitoxin system PrlF family antitoxin Antitoxin
LU680_RS25075 (LU680_25075) 5303718..5304185 + 468 WP_016713503.1 type II toxin-antitoxin system YhaV family toxin Toxin
LU680_RS25080 (LU680_25080) 5304231..5305091 - 861 WP_121757793.1 HlyD family secretion protein -
LU680_RS25085 (LU680_25085) 5305102..5305302 - 201 WP_009685040.1 DUF1656 domain-containing protein -
LU680_RS25090 (LU680_25090) 5305292..5307469 - 2178 WP_016713501.1 FUSC family protein -
LU680_RS25095 (LU680_25095) 5307466..5308995 - 1530 WP_016713500.1 efflux transporter outer membrane subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(17-152)

Antitoxin

PrlF antitoxin

(8-106)


Sequences

Toxin        


Download         Length: 156 a.a.        Molecular weight: 18037.56 Da        Isoelectric Point: 10.0504

>T284869 WP_016713503.1 NZ_CP128549:5303718-5304185 [Pseudomonas monteilii]
MSDASRKPLVIHGWTVIAHPLFLAKLEALSAQVQAQMHKDPTGYTRRNAYKRLAAIKRLAFDVIPQDPTKPEYRQGATLG
GDHKHWFRAKFFQQYRLFFRYHTPSRIIVLAWVNDESSKRAYESSDDAYKVFQKMLHTGHPPDDWEQLLREAAAE

Download         Length: 468 bp

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12007.46 Da        Isoelectric Point: 4.3118

>AT284869 WP_016713504.1 NZ_CP128549:5303395-5303721 [Pseudomonas monteilii]
MATTLDVESTLTDRYQTTVPETVRRALGLKKRDKIHYSIRPDGEVILTRAEATESDPVLGKFLDFLAHDIATNPQRLQVV
DADLIARLDKLVGDAEVDLDQSLSADDE

Download         Length: 327 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G2HLC0

Antitoxin

Source ID Structure
AlphaFold DB A0A0P7D0H8

References