Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 5157919..5158709 Replicon chromosome
Accession NZ_CP128546
Organism Pseudomonas monteilii strain NMI8712_11

Toxin (Protein)


Gene name yhaV Uniprot ID A0A3G2HLC0
Locus tag LU654_RS24165 Protein ID WP_016713503.1
Coordinates 5158242..5158709 (+) Length 156 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID A0A0P7D0H8
Locus tag LU654_RS24160 Protein ID WP_016713504.1
Coordinates 5157919..5158245 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LU654_RS24140 (LU654_024140) 5153455..5154516 - 1062 WP_016713508.1 HlyD family secretion protein -
LU654_RS24145 (LU654_024145) 5154545..5156086 - 1542 WP_016713507.1 MFS transporter -
LU654_RS24150 (LU654_024150) 5156203..5157108 - 906 WP_016713506.1 LysR family transcriptional regulator -
LU654_RS24155 (LU654_024155) 5157379..5157825 + 447 WP_016713505.1 universal stress protein -
LU654_RS24160 (LU654_024160) 5157919..5158245 + 327 WP_016713504.1 type II toxin-antitoxin system PrlF family antitoxin Antitoxin
LU654_RS24165 (LU654_024165) 5158242..5158709 + 468 WP_016713503.1 type II toxin-antitoxin system YhaV family toxin Toxin
LU654_RS24170 (LU654_024170) 5158755..5159615 - 861 WP_121757793.1 HlyD family secretion protein -
LU654_RS24175 (LU654_024175) 5159626..5159826 - 201 WP_009685040.1 DUF1656 domain-containing protein -
LU654_RS24180 (LU654_024180) 5159816..5161993 - 2178 WP_016713501.1 FUSC family protein -
LU654_RS24185 (LU654_024185) 5161990..5163519 - 1530 WP_016713500.1 efflux transporter outer membrane subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(17-152)

Antitoxin

PrlF antitoxin

(8-106)


Sequences

Toxin        


Download         Length: 156 a.a.        Molecular weight: 18037.56 Da        Isoelectric Point: 10.0504

>T284858 WP_016713503.1 NZ_CP128546:5158242-5158709 [Pseudomonas monteilii]
MSDASRKPLVIHGWTVIAHPLFLAKLEALSAQVQAQMHKDPTGYTRRNAYKRLAAIKRLAFDVIPQDPTKPEYRQGATLG
GDHKHWFRAKFFQQYRLFFRYHTPSRIIVLAWVNDESSKRAYESSDDAYKVFQKMLHTGHPPDDWEQLLREAAAE

Download         Length: 468 bp

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12007.46 Da        Isoelectric Point: 4.3118

>AT284858 WP_016713504.1 NZ_CP128546:5157919-5158245 [Pseudomonas monteilii]
MATTLDVESTLTDRYQTTVPETVRRALGLKKRDKIHYSIRPDGEVILTRAEATESDPVLGKFLDFLAHDIATNPQRLQVV
DADLIARLDKLVGDAEVDLDQSLSADDE

Download         Length: 327 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G2HLC0

Antitoxin

Source ID Structure
AlphaFold DB A0A0P7D0H8

References