Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 5192979..5193769 Replicon chromosome
Accession NZ_CP128545
Organism Pseudomonas monteilii strain NMI6266_12

Toxin (Protein)


Gene name yhaV Uniprot ID A0A3G2HLC0
Locus tag LU662_RS24740 Protein ID WP_016713503.1
Coordinates 5193302..5193769 (+) Length 156 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID A0A0P7D0H8
Locus tag LU662_RS24735 Protein ID WP_016713504.1
Coordinates 5192979..5193305 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LU662_RS24715 (LU662_024715) 5188515..5189576 - 1062 WP_016713508.1 HlyD family secretion protein -
LU662_RS24720 (LU662_024720) 5189605..5191146 - 1542 WP_016713507.1 MFS transporter -
LU662_RS24725 (LU662_024725) 5191263..5192168 - 906 WP_016713506.1 LysR family transcriptional regulator -
LU662_RS24730 (LU662_024730) 5192439..5192885 + 447 WP_016713505.1 universal stress protein -
LU662_RS24735 (LU662_024735) 5192979..5193305 + 327 WP_016713504.1 type II toxin-antitoxin system PrlF family antitoxin Antitoxin
LU662_RS24740 (LU662_024740) 5193302..5193769 + 468 WP_016713503.1 type II toxin-antitoxin system YhaV family toxin Toxin
LU662_RS24745 (LU662_024745) 5193815..5194675 - 861 WP_121757793.1 HlyD family secretion protein -
LU662_RS24750 (LU662_024750) 5194686..5194886 - 201 WP_009685040.1 DUF1656 domain-containing protein -
LU662_RS24755 (LU662_024755) 5194876..5197053 - 2178 WP_016713501.1 FUSC family protein -
LU662_RS24760 (LU662_024760) 5197050..5198579 - 1530 WP_016713500.1 efflux transporter outer membrane subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(17-152)

Antitoxin

PrlF antitoxin

(8-106)


Sequences

Toxin        


Download         Length: 156 a.a.        Molecular weight: 18037.56 Da        Isoelectric Point: 10.0504

>T284856 WP_016713503.1 NZ_CP128545:5193302-5193769 [Pseudomonas monteilii]
MSDASRKPLVIHGWTVIAHPLFLAKLEALSAQVQAQMHKDPTGYTRRNAYKRLAAIKRLAFDVIPQDPTKPEYRQGATLG
GDHKHWFRAKFFQQYRLFFRYHTPSRIIVLAWVNDESSKRAYESSDDAYKVFQKMLHTGHPPDDWEQLLREAAAE

Download         Length: 468 bp

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12007.46 Da        Isoelectric Point: 4.3118

>AT284856 WP_016713504.1 NZ_CP128545:5192979-5193305 [Pseudomonas monteilii]
MATTLDVESTLTDRYQTTVPETVRRALGLKKRDKIHYSIRPDGEVILTRAEATESDPVLGKFLDFLAHDIATNPQRLQVV
DADLIARLDKLVGDAEVDLDQSLSADDE

Download         Length: 327 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G2HLC0

Antitoxin

Source ID Structure
AlphaFold DB A0A0P7D0H8

References