Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 5256209..5256999 Replicon chromosome
Accession NZ_CP128541
Organism Pseudomonas monteilii strain NMI135_16

Toxin (Protein)


Gene name yhaV Uniprot ID A0A3G2HLC0
Locus tag LU690_RS24820 Protein ID WP_016713503.1
Coordinates 5256532..5256999 (+) Length 156 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID A0A0P7D0H8
Locus tag LU690_RS24815 Protein ID WP_016713504.1
Coordinates 5256209..5256535 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LU690_RS24795 (LU690_24795) 5251745..5252806 - 1062 WP_016713508.1 HlyD family secretion protein -
LU690_RS24800 (LU690_24800) 5252835..5254376 - 1542 WP_016713507.1 MFS transporter -
LU690_RS24805 (LU690_24805) 5254493..5255398 - 906 WP_016713506.1 LysR family transcriptional regulator -
LU690_RS24810 (LU690_24810) 5255669..5256115 + 447 WP_016713505.1 universal stress protein -
LU690_RS24815 (LU690_24815) 5256209..5256535 + 327 WP_016713504.1 type II toxin-antitoxin system PrlF family antitoxin Antitoxin
LU690_RS24820 (LU690_24820) 5256532..5256999 + 468 WP_016713503.1 type II toxin-antitoxin system YhaV family toxin Toxin
LU690_RS24825 (LU690_24825) 5257045..5257905 - 861 WP_121757793.1 HlyD family secretion protein -
LU690_RS24830 (LU690_24830) 5257916..5258116 - 201 WP_009685040.1 DUF1656 domain-containing protein -
LU690_RS24835 (LU690_24835) 5258106..5260283 - 2178 WP_016713501.1 FUSC family protein -
LU690_RS24840 (LU690_24840) 5260280..5261809 - 1530 WP_016713500.1 efflux transporter outer membrane subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(17-152)

Antitoxin

PrlF antitoxin

(8-106)


Sequences

Toxin        


Download         Length: 156 a.a.        Molecular weight: 18037.56 Da        Isoelectric Point: 10.0504

>T284841 WP_016713503.1 NZ_CP128541:5256532-5256999 [Pseudomonas monteilii]
MSDASRKPLVIHGWTVIAHPLFLAKLEALSAQVQAQMHKDPTGYTRRNAYKRLAAIKRLAFDVIPQDPTKPEYRQGATLG
GDHKHWFRAKFFQQYRLFFRYHTPSRIIVLAWVNDESSKRAYESSDDAYKVFQKMLHTGHPPDDWEQLLREAAAE

Download         Length: 468 bp

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12007.46 Da        Isoelectric Point: 4.3118

>AT284841 WP_016713504.1 NZ_CP128541:5256209-5256535 [Pseudomonas monteilii]
MATTLDVESTLTDRYQTTVPETVRRALGLKKRDKIHYSIRPDGEVILTRAEATESDPVLGKFLDFLAHDIATNPQRLQVV
DADLIARLDKLVGDAEVDLDQSLSADDE

Download         Length: 327 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G2HLC0

Antitoxin

Source ID Structure
AlphaFold DB A0A0P7D0H8

References