Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 1415106..1415707 Replicon chromosome
Accession NZ_CP128540
Organism Pseudomonas alloputida strain NMI24_14

Toxin (Protein)


Gene name higB Uniprot ID A0A2L1IAQ2
Locus tag LU682_RS06365 Protein ID WP_049587984.1
Coordinates 1415393..1415707 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A2L1IAR7
Locus tag LU682_RS06360 Protein ID WP_049587986.1
Coordinates 1415106..1415393 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LU682_RS06340 (LU682_006340) 1410138..1410983 + 846 WP_003254799.1 DUF6502 family protein -
LU682_RS06345 (LU682_006345) 1410980..1412698 + 1719 WP_010952348.1 DUF5666 domain-containing protein -
LU682_RS06350 (LU682_006350) 1412753..1413502 + 750 WP_049587988.1 hypothetical protein -
LU682_RS06355 (LU682_006355) 1413574..1414905 - 1332 WP_004576169.1 30S ribosomal protein S12 methylthiotransferase RimO -
LU682_RS06360 (LU682_006360) 1415106..1415393 - 288 WP_049587986.1 helix-turn-helix domain-containing protein Antitoxin
LU682_RS06365 (LU682_006365) 1415393..1415707 - 315 WP_049587984.1 hypothetical protein Toxin
LU682_RS06370 (LU682_006370) 1416156..1418066 + 1911 WP_010952353.1 potassium transporter Kup -
LU682_RS06375 (LU682_006375) 1418115..1419407 - 1293 WP_010952354.1 AcvB/VirJ family lysyl-phosphatidylglycerol hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-88)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11784.61 Da        Isoelectric Point: 9.9097

>T284832 WP_049587984.1 NZ_CP128540:c1415707-1415393 [Pseudomonas alloputida]
MIFIETPVFTSDLKEHLDDEEYRALQAYLAEHPEAGSLLEETGGLRKIRWAAKGKGKSGGVRVIYYHVTAAHQIRMILIY
RKGIVDTLTSSQKAQLRALNKGWK

Download         Length: 315 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10841.31 Da        Isoelectric Point: 7.4063

>AT284832 WP_049587986.1 NZ_CP128540:c1415393-1415106 [Pseudomonas alloputida]
MEKHLFDRLVESMTQMDEIDRGERQPSREFHVDALQVKKIRQATGLSQAAFAKRIDVAVGTLRNWEQGRREPEGPARALL
RAIHNDPEHVLAALS

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2L1IAQ2

Antitoxin

Source ID Structure
AlphaFold DB A0A2L1IAR7

References