Detailed information of TA system TA028483

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 837603..838135
• Replicon: chromosome
• Accession: NC_019673
• Organism: Saccharothrix espanaensis DSM 44229

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: K0JQZ2
• Locus tag: BN6_RS04080
• Protein ID: WP_015098270.1
• Coordinates: 837881..838135 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: BN6_RS04075
• Protein ID: WP_041311874.1
• Coordinates: 837603..837884 (+)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BN6_RS04060	834567..835073	-	507	WP_041311870.1	methylated-DNA--[protein]-cysteine S-methyltransferase	-
BN6_RS04065	835070..836338	-	1269	WP_051075929.1	DNA-3-methyladenine glycosylase 2 family protein	-
BN6_RS04070	836418..837497	+	1080	WP_041311872.1	redox-regulated ATPase YchF	-
BN6_RS04075	837603..837884	+	282	WP_041311874.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
BN6_RS04080	837881..838135	+	255	WP_015098270.1	Txe/YoeB family addiction module toxin	Toxin
BN6_RS04085	838459..839664	+	1206	WP_015098272.1	mannosyltransferase	-
BN6_RS04090	839620..839913	-	294	WP_015098273.1	4a-hydroxytetrahydrobiopterin dehydratase	-
BN6_RS04095	840051..841085	+	1035	WP_015098274.1	thiamine ABC transporter substrate-binding protein	-
BN6_RS04100	841364..842911	+	1548	WP_041311876.1	iron ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (2-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-65)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10095.61 Da
• Isoelectric Point: 6.7259

>T28483 WP_015098270.1 NC_019673:837881-838135 [Saccharothrix espanaensis DSM 44229]
VRLVFENQGWEDYTSWLKNDRKMLVRINKLIEDVLRDPFTGIGKPEPLKFHLPGAWSRRIDDEHRLVYLVTDEEIIVLAA
RYHY

Nucleotide

• Length: 255 bp

>T28483 NC_019673:837881-838135 [Saccharothrix espanaensis DSM 44229]
GTGAGGCTCGTTTTCGAGAACCAGGGCTGGGAGGACTACACGTCCTGGTTGAAGAACGACCGGAAGATGCTCGTCCGGAT
CAACAAGCTCATCGAGGACGTCCTGCGGGATCCGTTCACGGGGATCGGCAAGCCGGAGCCGTTGAAGTTCCACCTGCCCG
GGGCTTGGTCGCGGCGCATCGACGACGAGCACCGCCTCGTCTACCTCGTCACCGACGAGGAGATCATCGTGCTGGCCGCT
CGCTACCACTACTGA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10148.34 Da
• Isoelectric Point: 6.4715

>AT28483 WP_041311874.1 NC_019673:837603-837884 [Saccharothrix espanaensis DSM 44229]
VSVTASKARKDLFPLIKKVNEDHDAIEIVSKHGNAVLVSAEDYASLREGSYLLRSPANARRLLKSYENALGRADVSEREL
INPDQADAERGGA

Nucleotide

• Length: 282 bp

>AT28483 NC_019673:837603-837884 [Saccharothrix espanaensis DSM 44229]
GTGTCCGTCACCGCGAGTAAAGCGCGCAAGGACCTGTTCCCACTGATCAAGAAGGTCAACGAGGATCACGACGCGATCGA
GATCGTCTCGAAGCACGGGAACGCGGTGCTCGTCTCGGCCGAGGACTACGCGTCCTTGCGCGAGGGGTCGTACCTCCTCC
GCTCGCCGGCGAACGCCCGCCGTCTGCTCAAGTCCTACGAGAACGCGCTCGGTCGCGCCGACGTGTCCGAGCGCGAGCTG
ATCAACCCCGATCAGGCGGATGCGGAGCGCGGCGGCGCGTGA

Structures

Toxin

• AlphaFold DB: K0JQZ2