Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ(toxin)
Location 370053..370539 Replicon chromosome
Accession NC_019563
Organism Helicobacter pylori Aklavik86

Toxin (Protein)


Gene name TfiT Uniprot ID -
Locus tag HPAKL86_RS01920 Protein ID WP_015086800.1
Coordinates 370053..370262 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TfiA Uniprot ID -
Locus tag HPAKL86_RS01925 Protein ID WP_041200228.1
Coordinates 370255..370539 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HPAKL86_RS01890 365958..366569 + 612 WP_015086795.1 translation initiation factor IF-3 -
HPAKL86_RS01895 366550..366744 + 195 WP_001125541.1 50S ribosomal protein L35 -
HPAKL86_RS01900 366840..367190 + 351 WP_001264172.1 50S ribosomal protein L20 -
HPAKL86_RS01905 367361..368221 + 861 WP_015086796.1 outer membrane protein -
HPAKL86_RS01910 368463..368894 + 432 WP_015086797.1 DUF1104 domain-containing protein -
HPAKL86_RS01915 369143..370021 + 879 WP_015086799.1 hypothetical protein -
HPAKL86_RS01920 370053..370262 - 210 WP_015086800.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
HPAKL86_RS01925 370255..370539 - 285 WP_041200228.1 hypothetical protein Antitoxin
HPAKL86_RS01930 370770..373142 - 2373 WP_015086802.1 TonB-dependent receptor family protein -
HPAKL86_RS01935 373321..374193 - 873 WP_041200229.1 SPASM domain-containing protein -
HPAKL86_RS01940 374227..375327 - 1101 WP_015086804.1 redox-regulated ATPase YchF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(3-61)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7951.33 Da        Isoelectric Point: 10.0738

>T28473 WP_015086800.1 NC_019563:c370262-370053 [Helicobacter pylori Aklavik86]
MLKVRTKKDFLKDFNKHILSGRITESDVASVVDCLKEQKPLQQKYCDHALSGNLKGLRECHNALIQRKL

Download         Length: 210 bp

>T28473 NC_019563:c370262-370053 [Helicobacter pylori Aklavik86]
ATGCTTAAAGTCAGAACTAAGAAAGATTTTCTTAAAGACTTTAATAAGCATATCTTATCTGGGCGTATTACAGAAAGCGA
TGTTGCAAGCGTTGTTGATTGTCTCAAAGAGCAAAAACCACTCCAACAAAAATATTGCGACCATGCCTTGAGTGGCAATC
TTAAAGGGTTGAGAGAATGCCATAACGCACTCATTCAAAGAAAGCTTTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 11012.43 Da        Isoelectric Point: 5.7573

>AT28473 WP_041200228.1 NC_019563:c370539-370255 [Helicobacter pylori Aklavik86]
ILNEKQLHFLNSIEKQLLKAEGDKNKAIKKIQECELQEQMIRQVLAQKHSQEKEPTQSLLNTIASKDDPEYDVSFGDFND
FLQIAKQERERRNA

Download         Length: 285 bp

>AT28473 NC_019563:c370539-370255 [Helicobacter pylori Aklavik86]
ATTCTAAATGAAAAACAACTGCATTTCTTAAACTCCATTGAAAAACAATTGCTTAAGGCAGAAGGGGATAAAAATAAGGC
GATAAAAAAAATCCAAGAGTGTGAATTGCAAGAACAAATGATCAGACAAGTTTTAGCCCAAAAACATTCTCAAGAAAAAG
AACCCACACAAAGTTTGTTAAATACGATCGCCTCAAAAGATGACCCAGAATACGATGTTTCGTTTGGAGACTTCAATGAT
TTTTTACAAATAGCAAAACAAGAAAGAGAAAGGCGTAATGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References