28470

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-Phd
Location 2539135..2539631 Replicon chromosome
Accession NC_019427
Organism Anabaena sp. 90

Toxin (Protein)


Gene name yoeB Uniprot ID K7W1R6
Locus tag ANA_RS11070 Protein ID WP_015080149.1
Coordinates 2539368..2539631 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID K7WWK3
Locus tag ANA_RS11065 Protein ID WP_015080148.1
Coordinates 2539135..2539371 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ANA_RS11045 2534994..2536775 + 1782 WP_015080144.1 UvrD-helicase domain-containing protein -
ANA_RS11050 2537082..2537483 - 402 WP_015080145.1 hypothetical protein -
ANA_RS11055 2537606..2537893 - 288 WP_015080146.1 type II toxin-antitoxin system HigB family toxin -
ANA_RS11060 2538462..2538689 + 228 WP_015080147.1 virulence associated protein B -
ANA_RS24545 2538690..2538785 + 96 Protein_2295 VapC toxin family PIN domain ribonuclease -
ANA_RS11065 2539135..2539371 + 237 WP_015080148.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
ANA_RS11070 2539368..2539631 + 264 WP_015080149.1 Txe/YoeB family addiction module toxin Toxin
ANA_RS26545 2539624..2539776 + 153 WP_015080150.1 hypothetical protein -
ANA_RS25900 2539764..2539901 + 138 WP_174782923.1 hypothetical protein -
ANA_RS11075 2539981..2541075 + 1095 WP_015080151.1 RIP metalloprotease RseP -
ANA_RS11080 2541414..2542088 + 675 WP_015080152.1 endonuclease III -
ANA_RS11085 2542192..2542494 + 303 WP_015080153.1 30S ribosomal protein S14 -
ANA_RS11090 2542614..2542943 - 330 WP_015080154.1 hypothetical protein -
ANA_RS11095 2543002..2543577 + 576 WP_015080155.1 leucyl/phenylalanyl-tRNA--protein transferase -
ANA_RS11105 2543813..2544475 - 663 WP_015080157.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(22-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-69)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10268.77 Da        Isoelectric Point: 9.6964

>T28470 WP_015080149.1 NC_019427:2539368-2539631 [Anabaena sp. 90]
VNWNLVYTKQAQKDAKKLAASNLKDKAQSLLDIIQINPFQNPPPYEKLVGDLERAYSRRINIQHRLVYEVIESENTAKIL
RMWTHYE

Download         Length: 264 bp

>T28470 NC_019427:2539368-2539631 [Anabaena sp. 90]
GTGAATTGGAATTTAGTTTATACTAAACAAGCTCAGAAAGATGCTAAAAAATTGGCTGCAAGTAATTTAAAAGATAAAGC
ACAAAGCTTACTTGATATTATTCAAATCAATCCGTTTCAAAATCCCCCACCTTATGAGAAATTAGTCGGAGATTTAGAAC
GTGCATATTCACGACGGATTAATATTCAACATCGGTTAGTCTATGAAGTAATTGAATCTGAAAATACGGCCAAAATTTTA
CGAATGTGGACTCATTATGAATAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8590.67 Da        Isoelectric Point: 3.9169

>AT28470 WP_015080148.1 NC_019427:2539135-2539371 [Anabaena sp. 90]
MISINQAKQQLQDLIDSVNQSHQPIVIAGDNSNAVLLSEADWKSIQETLYLLSIPGIRESIKEGLATPIAECDGELEW

Download         Length: 237 bp

>AT28470 NC_019427:2539135-2539371 [Anabaena sp. 90]
ATGATTTCAATTAATCAAGCAAAACAACAATTACAGGATTTAATTGATTCAGTCAATCAGTCTCATCAACCTATTGTTAT
TGCCGGAGACAATAGCAACGCAGTATTATTGTCTGAAGCAGACTGGAAATCTATCCAAGAAACTCTTTATCTTCTTTCTA
TTCCAGGAATACGGGAATCAATTAAAGAAGGATTAGCAACACCGATTGCAGAATGTGATGGGGAATTAGAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K7W1R6

Antitoxin

Source ID Structure
AlphaFold DB A0A844ILF8

References