Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5405418..5406013 Replicon chromosome
Accession NZ_CP128507
Organism Pseudomonas aeruginosa strain WS27-3

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag QUC27_RS25165 Protein ID WP_003113526.1
Coordinates 5405735..5406013 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QUC27_RS25160 Protein ID WP_003099268.1
Coordinates 5405418..5405723 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUC27_RS25125 (QUC27_25125) 5400557..5401405 + 849 WP_003117426.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
QUC27_RS25135 (QUC27_25135) 5401572..5402513 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
QUC27_RS25140 (QUC27_25140) 5402630..5403244 + 615 WP_003099279.1 50S ribosomal protein L25/general stress protein Ctc -
QUC27_RS25145 (QUC27_25145) 5403286..5403870 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
QUC27_RS25150 (QUC27_25150) 5403911..5405011 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
QUC27_RS25160 (QUC27_25160) 5405418..5405723 - 306 WP_003099268.1 HigA family addiction module antitoxin Antitoxin
QUC27_RS25165 (QUC27_25165) 5405735..5406013 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QUC27_RS25170 (QUC27_25170) 5406066..5406194 - 129 Protein_4972 integrase -
QUC27_RS25175 (QUC27_25175) 5406342..5408570 + 2229 WP_021264080.1 TonB-dependent receptor -
QUC27_RS25180 (QUC27_25180) 5408640..5409287 - 648 WP_003095021.1 carbonate dehydratase -
QUC27_RS25185 (QUC27_25185) 5409349..5410587 - 1239 WP_121295756.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T284681 WP_003113526.1 NZ_CP128507:c5406013-5405735 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11213.79 Da        Isoelectric Point: 5.0747

>AT284681 WP_003099268.1 NZ_CP128507:c5405723-5405418 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References