Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5366756..5367351 Replicon chromosome
Accession NZ_CP128506
Organism Pseudomonas aeruginosa strain Fe11-1

Toxin (Protein)


Gene name higB Uniprot ID A0A241XLJ5
Locus tag QUC24_RS24855 Protein ID WP_003117425.1
Coordinates 5367073..5367351 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QUC24_RS24850 Protein ID WP_003113527.1
Coordinates 5366756..5367061 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUC24_RS24835 (QUC24_24835) 5362093..5363529 + 1437 WP_023122806.1 HAD-IA family hydrolase -
QUC24_RS24840 (QUC24_24840) 5363533..5364492 + 960 WP_078459576.1 DNA-processing protein DprA -
QUC24_RS24845 (QUC24_24845) 5364527..5365399 - 873 WP_023122808.1 DUF4868 domain-containing protein -
QUC24_RS24850 (QUC24_24850) 5366756..5367061 - 306 WP_003113527.1 HigA family addiction module antitoxin Antitoxin
QUC24_RS24855 (QUC24_24855) 5367073..5367351 - 279 WP_003117425.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QUC24_RS24860 (QUC24_24860) 5367404..5367532 - 129 Protein_4910 integrase -
QUC24_RS24865 (QUC24_24865) 5367680..5369908 + 2229 WP_003113525.1 TonB-dependent receptor -
QUC24_RS24870 (QUC24_24870) 5369978..5370625 - 648 WP_003095021.1 carbonate dehydratase -
QUC24_RS24875 (QUC24_24875) 5370687..5371925 - 1239 WP_014603324.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10701.28 Da        Isoelectric Point: 8.5576

>T284675 WP_003117425.1 NZ_CP128506:c5367351-5367073 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAARELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11247.81 Da        Isoelectric Point: 5.0747

>AT284675 WP_003113527.1 NZ_CP128506:c5367061-5366756 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMEFDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241XLJ5

Antitoxin

Source ID Structure

References