284670

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5393731..5394326 Replicon chromosome
Accession NZ_CP128505
Organism Pseudomonas aeruginosa strain Fe8-1

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag QUC25_RS24995 Protein ID WP_003113526.1
Coordinates 5394048..5394326 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QUC25_RS24990 Protein ID WP_003133769.1
Coordinates 5393731..5394036 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUC25_RS24960 (QUC25_24960) 5389297..5389587 - 291 WP_023083237.1 DUF5447 family protein -
QUC25_RS24965 (QUC25_24965) 5389763..5390035 - 273 WP_004352675.1 hypothetical protein -
QUC25_RS24970 (QUC25_24970) 5390476..5390811 + 336 WP_025921265.1 hypothetical protein -
QUC25_RS24975 (QUC25_24975) 5390972..5392348 + 1377 WP_071534372.1 DUF3696 domain-containing protein -
QUC25_RS24980 (QUC25_24980) 5392345..5392827 + 483 WP_071534371.1 hypothetical protein -
QUC25_RS24985 (QUC25_24985) 5392988..5393395 - 408 WP_052151012.1 hypothetical protein -
QUC25_RS24990 (QUC25_24990) 5393731..5394036 - 306 WP_003133769.1 HigA family addiction module antitoxin Antitoxin
QUC25_RS24995 (QUC25_24995) 5394048..5394326 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QUC25_RS25000 (QUC25_25000) 5394379..5394507 - 129 Protein_4938 integrase -
QUC25_RS25005 (QUC25_25005) 5394655..5396883 + 2229 WP_021264080.1 TonB-dependent receptor -
QUC25_RS25010 (QUC25_25010) 5396954..5397601 - 648 WP_003095021.1 carbonate dehydratase -
QUC25_RS25015 (QUC25_25015) 5397663..5398901 - 1239 WP_043085810.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T284670 WP_003113526.1 NZ_CP128505:c5394326-5394048 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11214.73 Da        Isoelectric Point: 4.6081

>AT284670 WP_003133769.1 NZ_CP128505:c5394036-5393731 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References