Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 4734247..4734928 Replicon chromosome
Accession NZ_CP128505
Organism Pseudomonas aeruginosa strain Fe8-1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag QUC25_RS21905 Protein ID WP_015503432.1
Coordinates 4734563..4734928 (-) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A643IYQ7
Locus tag QUC25_RS21900 Protein ID WP_034071998.1
Coordinates 4734247..4734570 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QUC25_RS21875 (QUC25_21875) 4730563..4731201 + 639 WP_003109444.1 hypothetical protein -
QUC25_RS21880 (QUC25_21880) 4731444..4731779 + 336 WP_060853238.1 TM2 domain-containing protein -
QUC25_RS21885 (QUC25_21885) 4731953..4732471 + 519 WP_003140886.1 PAAR domain-containing protein -
QUC25_RS21890 (QUC25_21890) 4732468..4732713 + 246 WP_289344355.1 hypothetical protein -
QUC25_RS21895 (QUC25_21895) 4732783..4733871 + 1089 WP_003140888.1 DUF3396 domain-containing protein -
QUC25_RS21900 (QUC25_21900) 4734247..4734570 - 324 WP_034071998.1 XRE family transcriptional regulator Antitoxin
QUC25_RS21905 (QUC25_21905) 4734563..4734928 - 366 WP_015503432.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QUC25_RS21910 (QUC25_21910) 4735192..4735431 - 240 WP_048521765.1 hypothetical protein -
QUC25_RS21915 (QUC25_21915) 4735638..4735910 + 273 WP_003124230.1 hypothetical protein -
QUC25_RS21920 (QUC25_21920) 4735941..4736366 - 426 WP_003116492.1 VOC family protein -
QUC25_RS21925 (QUC25_21925) 4736467..4737351 + 885 WP_003140892.1 LysR substrate-binding domain-containing protein -
QUC25_RS21930 (QUC25_21930) 4737324..4738277 - 954 WP_289344356.1 LysR substrate-binding domain-containing protein -
QUC25_RS21935 (QUC25_21935) 4738498..4738932 + 435 WP_003158601.1 RidA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-105)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-86)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13798.14 Da        Isoelectric Point: 4.8219

>T284669 WP_015503432.1 NZ_CP128505:c4734928-4734563 [Pseudomonas aeruginosa]
VAWDIEYTDEFGDWWGSLSEDEQESLAVTVRLLEERGPSLGHPHSSGINGSRPGHMRELRTQHGGRPFRTLYAFDPRRSA
ILPIGGDKTGDDRWYELNVPIADRLHDEHLHQLREEGLIDG

Download         Length: 366 bp

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11926.76 Da        Isoelectric Point: 6.4751

>AT284669 WP_034071998.1 NZ_CP128505:c4734570-4734247 [Pseudomonas aeruginosa]
MAKKFSDLRAQMSPEAQARVEAKAQELLAEMPLNELRQARGLSQKMLSEVLQVQQPAIAKMERRTDMYISTLRSHIEAMG
GHLEVIARFPDGAVKISNFADIEETGA

Download         Length: 324 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A643IYQ7

References