Detailed information of TA system TA028465

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 1314787..1315349
• Replicon: chromosome
• Accession: NC_019395
• Organism: Propionibacterium acidipropionici ATCC 4875

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: PACID_RS05905
• Protein ID: WP_051143495.1
• Coordinates: 1315116..1315349 (-)
• Length: 78 a.a.

Antitoxin (Protein)

• Gene name: graA
• Uniprot ID: -
• Locus tag: PACID_RS05900
• Protein ID: WP_015069931.1
• Coordinates: 1314787..1315092 (-)
• Length: 102 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PACID_RS05880	1310926..1312218	-	1293	WP_015069928.1	threonine/serine exporter family protein	-
PACID_RS05885	1312226..1313044	-	819	WP_015069929.1	Nif3-like dinuclear metal center hexameric protein	-
PACID_RS05890	1313169..1314185	+	1017	WP_015069930.1	YdcF family protein	-
PACID_RS05900	1314787..1315092	-	306	WP_015069931.1	HigA family addiction module antidote protein	Antitoxin
PACID_RS05905	1315116..1315349	-	234	WP_051143495.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
PACID_RS05910	1315405..1316826	-	1422	WP_015069932.1	type I glutamate--ammonia ligase	-
PACID_RS05915	1317039..1318328	+	1290	WP_015069933.1	hypothetical protein	-
PACID_RS05920	1318460..1318786	+	327	WP_148279616.1	RDD family protein	-
PACID_RS05925	1318791..1319924	+	1134	WP_015069935.1	glycosyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (18-77)

Antitoxin

• Cro/C1-type helix-turn-helix domain (25-72)

Sequences

Toxin

Protein

• Length: 78 a.a.
• Molecular weight: 8594.62 Da
• Isoelectric Point: 6.6970

>T28465 WP_051143495.1 NC_019395:c1315349-1315116 [Acidipropionibacterium acidipropionici ATCC 4875]
IIRPCCQHFTNGSTGGLVRLLNAASELNSLRVPPGNRLEKLVGGRDGQHSIRINDQYRICFVWTDNGADDVEITDYH

Nucleotide

• Length: 234 bp

>T28465 NC_019395:c1315349-1315116 [Acidipropionibacterium acidipropionici ATCC 4875]
ATCATCCGCCCGTGCTGCCAGCACTTCACCAACGGCAGCACGGGCGGACTCGTTCGCCTCCTCAACGCGGCCTCAGAACT
GAACAGCCTTCGGGTGCCGCCGGGAAATCGCTTGGAGAAGCTGGTCGGCGGCCGCGACGGCCAGCACTCCATCCGCATCA
ACGACCAGTACCGAATCTGCTTCGTGTGGACCGACAACGGAGCAGACGACGTCGAGATCACCGACTATCACTGA

Antitoxin

Protein

• Length: 102 a.a.
• Molecular weight: 11168.69 Da
• Isoelectric Point: 4.8182

>AT28465 WP_015069931.1 NC_019395:c1315092-1314787 [Acidipropionibacterium acidipropionici ATCC 4875]
MATASKAHDPITPGEILLTEFLEPMGITQYRLAQATGLSQTRISEIVRGKRAITTDTAPRLSKALGVDDRFWINIQTDYD
LEVERDLHADELAKVTTLVAS

Nucleotide

• Length: 306 bp

>AT28465 NC_019395:c1315092-1314787 [Acidipropionibacterium acidipropionici ATCC 4875]
ATGGCGACAGCATCGAAGGCACACGACCCGATCACTCCCGGCGAGATCCTGCTGACTGAGTTTCTTGAGCCGATGGGCAT
CACGCAGTACCGCCTCGCCCAGGCCACTGGACTCTCCCAGACCCGGATCAGCGAGATCGTGCGCGGCAAGCGCGCCATCA
CCACCGATACCGCCCCCCGGCTGTCCAAGGCCCTCGGGGTCGACGACCGCTTCTGGATCAACATCCAGACCGACTACGAC
CTCGAGGTCGAGCGAGACCTGCACGCCGACGAACTGGCCAAGGTGACCACTCTGGTCGCGAGCTGA