Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1314787..1315349 Replicon chromosome
Accession NC_019395
Organism Propionibacterium acidipropionici ATCC 4875

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag PACID_RS05905 Protein ID WP_051143495.1
Coordinates 1315116..1315349 (-) Length 78 a.a.

Antitoxin (Protein)


Gene name graA Uniprot ID -
Locus tag PACID_RS05900 Protein ID WP_015069931.1
Coordinates 1314787..1315092 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PACID_RS05880 1310926..1312218 - 1293 WP_015069928.1 threonine/serine exporter family protein -
PACID_RS05885 1312226..1313044 - 819 WP_015069929.1 Nif3-like dinuclear metal center hexameric protein -
PACID_RS05890 1313169..1314185 + 1017 WP_015069930.1 YdcF family protein -
PACID_RS05900 1314787..1315092 - 306 WP_015069931.1 HigA family addiction module antidote protein Antitoxin
PACID_RS05905 1315116..1315349 - 234 WP_051143495.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PACID_RS05910 1315405..1316826 - 1422 WP_015069932.1 type I glutamate--ammonia ligase -
PACID_RS05915 1317039..1318328 + 1290 WP_015069933.1 hypothetical protein -
PACID_RS05920 1318460..1318786 + 327 WP_148279616.1 RDD family protein -
PACID_RS05925 1318791..1319924 + 1134 WP_015069935.1 glycosyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(18-77)

Antitoxin

Cro/C1-type helix-turn-helix domain

(25-72)


Sequences

Toxin        


Download         Length: 78 a.a.        Molecular weight: 8594.62 Da        Isoelectric Point: 6.6970

>T28465 WP_051143495.1 NC_019395:c1315349-1315116 [Acidipropionibacterium acidipropionici ATCC 4875]
IIRPCCQHFTNGSTGGLVRLLNAASELNSLRVPPGNRLEKLVGGRDGQHSIRINDQYRICFVWTDNGADDVEITDYH

Download         Length: 234 bp

>T28465 NC_019395:c1315349-1315116 [Acidipropionibacterium acidipropionici ATCC 4875]
ATCATCCGCCCGTGCTGCCAGCACTTCACCAACGGCAGCACGGGCGGACTCGTTCGCCTCCTCAACGCGGCCTCAGAACT
GAACAGCCTTCGGGTGCCGCCGGGAAATCGCTTGGAGAAGCTGGTCGGCGGCCGCGACGGCCAGCACTCCATCCGCATCA
ACGACCAGTACCGAATCTGCTTCGTGTGGACCGACAACGGAGCAGACGACGTCGAGATCACCGACTATCACTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11168.69 Da        Isoelectric Point: 4.8182

>AT28465 WP_015069931.1 NC_019395:c1315092-1314787 [Acidipropionibacterium acidipropionici ATCC 4875]
MATASKAHDPITPGEILLTEFLEPMGITQYRLAQATGLSQTRISEIVRGKRAITTDTAPRLSKALGVDDRFWINIQTDYD
LEVERDLHADELAKVTTLVAS

Download         Length: 306 bp

>AT28465 NC_019395:c1315092-1314787 [Acidipropionibacterium acidipropionici ATCC 4875]
ATGGCGACAGCATCGAAGGCACACGACCCGATCACTCCCGGCGAGATCCTGCTGACTGAGTTTCTTGAGCCGATGGGCAT
CACGCAGTACCGCCTCGCCCAGGCCACTGGACTCTCCCAGACCCGGATCAGCGAGATCGTGCGCGGCAAGCGCGCCATCA
CCACCGATACCGCCCCCCGGCTGTCCAAGGCCCTCGGGGTCGACGACCGCTTCTGGATCAACATCCAGACCGACTACGAC
CTCGAGGTCGAGCGAGACCTGCACGCCGACGAACTGGCCAAGGTGACCACTCTGGTCGCGAGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References