Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 729302..730077 Replicon chromosome
Accession NZ_CP128487
Organism Klebsiella pneumoniae strain YZEF2-2C

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag QTN20_RS05610 Protein ID WP_004150910.1
Coordinates 729592..730077 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag QTN20_RS05605 Protein ID WP_004150912.1
Coordinates 729302..729595 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QTN20_RS05585 (724510) 724510..725112 - 603 WP_002916735.1 short chain dehydrogenase -
QTN20_RS05590 (725210) 725210..726121 + 912 WP_004188550.1 LysR family transcriptional regulator -
QTN20_RS05595 (726122) 726122..727270 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
QTN20_RS05600 (727281) 727281..728657 - 1377 WP_004217775.1 cystathionine beta-synthase -
QTN20_RS05605 (729302) 729302..729595 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
QTN20_RS05610 (729592) 729592..730077 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
QTN20_RS05615 (730781) 730781..731374 + 594 WP_004188553.1 hypothetical protein -
QTN20_RS05620 (731471) 731471..731687 + 217 Protein_711 transposase -
QTN20_RS05625 (732293) 732293..733165 + 873 WP_004188557.1 ParA family protein -
QTN20_RS05630 (733165) 733165..733548 + 384 WP_004150906.1 hypothetical protein -
QTN20_RS05635 (733541) 733541..734908 + 1368 WP_004150905.1 SPI-7-type island replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 731471..731623 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T284634 WP_004150910.1 NZ_CP128487:729592-730077 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT284634 WP_004150912.1 NZ_CP128487:729302-729595 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References