Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 69048..69775 | Replicon | plasmid pYZEF2-2C_tmex |
| Accession | NZ_CP128484 | ||
| Organism | Klebsiella pneumoniae strain YZEF2-2C | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | A0A7W3D9W1 |
| Locus tag | QTN20_RS00350 | Protein ID | WP_011251285.1 |
| Coordinates | 69464..69775 (-) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | QTN20_RS00345 | Protein ID | WP_011251286.1 |
| Coordinates | 69048..69467 (-) | Length | 140 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QTN20_RS00325 (QTN20_00325) | 64573..65334 | - | 762 | WP_017900871.1 | histidine utilization repressor | - |
| QTN20_RS00330 (QTN20_00330) | 65437..66804 | + | 1368 | WP_032437385.1 | formimidoylglutamate deiminase | - |
| QTN20_RS00335 (QTN20_00335) | 67329..67864 | + | 536 | Protein_66 | transposase | - |
| QTN20_RS00340 (QTN20_00340) | 67933..68901 | - | 969 | WP_077268729.1 | IS5 family transposase | - |
| QTN20_RS00345 (QTN20_00345) | 69048..69467 | - | 420 | WP_011251286.1 | helix-turn-helix domain-containing protein | Antitoxin |
| QTN20_RS00350 (QTN20_00350) | 69464..69775 | - | 312 | WP_011251285.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| QTN20_RS00355 (QTN20_00355) | 69980..70417 | - | 438 | Protein_70 | DDE-type integrase/transposase/recombinase | - |
| QTN20_RS00360 (QTN20_00360) | 70531..70869 | + | 339 | WP_023288266.1 | transposase | - |
| QTN20_RS00365 (QTN20_00365) | 70866..71213 | + | 348 | WP_004114612.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| QTN20_RS00370 (QTN20_00370) | 71262..72790 | + | 1529 | Protein_73 | IS66 family transposase | - |
| QTN20_RS00375 (QTN20_00375) | 72830..73009 | + | 180 | Protein_74 | IS5/IS1182 family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | IScluster/Tn | - | - | 67470..77699 | 10229 | |
| - | inside | Non-Mobilizable plasmid | aph(3'')-Ib / aph(6)-Id / aph(4)-Ia / aac(3)-IVa / sul3 / ant(3'')-Ia / cmlA1 / aadA2 | - | 1..207962 | 207962 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12346.12 Da Isoelectric Point: 9.7248
>T284630 WP_011251285.1 NZ_CP128484:c69775-69464 [Klebsiella pneumoniae]
MHVISKEPFEEAAKRYPNDSLAIRALYRLVRETDFSSPAEMLTLIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFVNKRF
YVKHIATHADYDKLTRYYRENKE
MHVISKEPFEEAAKRYPNDSLAIRALYRLVRETDFSSPAEMLTLIPSLDNFKYRNKWWVLDVGGNNLRVIAYINFVNKRF
YVKHIATHADYDKLTRYYRENKE
Download Length: 312 bp
Antitoxin
Download Length: 140 a.a. Molecular weight: 15377.46 Da Isoelectric Point: 4.4420
>AT284630 WP_011251286.1 NZ_CP128484:c69467-69048 [Klebsiella pneumoniae]
MITDTAKAIEATKQLVAAVPFLGGSSSESDYREAMELVDYLIENDDENPLIDFLASKIADYEDNSPRFAEFNKAIAEIPV
GVALLRTLIDQHKLSYSDLKDEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL
MITDTAKAIEATKQLVAAVPFLGGSSSESDYREAMELVDYLIENDDENPLIDFLASKIADYEDNSPRFAEFNKAIAEIPV
GVALLRTLIDQHKLSYSDLKDEIGSKSLVSQILSGQRSLTITHIKALSARFGVKPEWFL
Download Length: 420 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|