Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 4049091..4049688 Replicon chromosome
Accession NZ_CP128466
Organism Klebsiella variicola strain 22KM2707

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag QSV42_RS20080 Protein ID WP_012968756.1
Coordinates 4049371..4049688 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QSV42_RS20075 Protein ID WP_012542525.1
Coordinates 4049091..4049378 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QSV42_RS20045 (QSV42_20040) 4045001..4045249 + 249 WP_008805539.1 DUF1158 domain-containing protein -
QSV42_RS20050 (QSV42_20045) 4045266..4045607 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
QSV42_RS20055 (QSV42_20050) 4045638..4046753 - 1116 WP_162493283.1 MBL fold metallo-hydrolase -
QSV42_RS20060 (QSV42_20055) 4046933..4047514 + 582 WP_012968754.1 TetR/AcrR family transcriptional regulator -
QSV42_RS20065 (QSV42_20060) 4047514..4047882 + 369 WP_008805536.1 MmcQ/YjbR family DNA-binding protein -
QSV42_RS20070 (QSV42_20065) 4048002..4048655 + 654 WP_012968755.1 oxygen-insensitive NAD(P)H nitroreductase -
QSV42_RS20075 (QSV42_20070) 4049091..4049378 - 288 WP_012542525.1 helix-turn-helix transcriptional regulator Antitoxin
QSV42_RS20080 (QSV42_20075) 4049371..4049688 - 318 WP_012968756.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QSV42_RS20085 (QSV42_20080) 4049873..4050916 - 1044 WP_016160437.1 DUF2157 domain-containing protein -
QSV42_RS20090 (QSV42_20085) 4051446..4052312 - 867 WP_008805530.1 helix-turn-helix transcriptional regulator -
QSV42_RS20095 (QSV42_20090) 4052421..4053848 + 1428 WP_049009040.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-89)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12124.41 Da        Isoelectric Point: 11.2767

>T284619 WP_012968756.1 NZ_CP128466:c4049688-4049371 [Klebsiella variicola]
MFRLVVHVDVKKELQALPPIVQAKMIRQIDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
IKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10815.51 Da        Isoelectric Point: 10.2212

>AT284619 WP_012542525.1 NZ_CP128466:c4049378-4049091 [Klebsiella variicola]
MSKKIIDWDTLKTELLSQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQILLY

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References