Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2427301..2427959 Replicon chromosome
Accession NZ_CP128435
Organism Morganella morganii subsp. morganii strain QLYYMMQL588

Toxin (Protein)


Gene name higB Uniprot ID A0A7T9XFK0
Locus tag QSV29_RS11940 Protein ID WP_024473887.1
Coordinates 2427606..2427959 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID J7TDD0
Locus tag QSV29_RS11935 Protein ID WP_004236876.1
Coordinates 2427301..2427603 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QSV29_RS11895 2423667..2424362 - 696 WP_024473885.1 MgtC family protein -
QSV29_RS11900 2424713..2424907 - 195 WP_015422621.1 protein DsrB -
QSV29_RS11905 2425011..2425223 - 213 WP_004240014.1 transcription antiterminator/RNA stability regulator CspE -
QSV29_RS11910 2425684..2426193 + 510 WP_024473886.1 YlaC family protein -
QSV29_RS11935 2427301..2427603 - 303 WP_004236876.1 XRE family transcriptional regulator Antitoxin
QSV29_RS11940 2427606..2427959 - 354 WP_024473887.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QSV29_RS11945 2428236..2429288 + 1053 WP_024473888.1 dihydroorotase -
QSV29_RS11950 2429523..2429780 + 258 WP_024473889.1 biofilm formation regulator BssS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(33-81)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13648.63 Da        Isoelectric Point: 9.9631

>T284567 WP_024473887.1 NZ_CP128435:c2427959-2427606 [Morganella morganii subsp. morganii]
VWKIVTTDNFTVWFAEQDDGDRAAILAAMLVLEKRGPGLPRPYADTVKGSRYTNMKELRIQSRGQPIRAFFAFDPERRGV
LLCAGYKTGKEKRFYMQMIPQADREYTEWLNRPENRS

Download         Length: 354 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11108.00 Da        Isoelectric Point: 9.5930

>AT284567 WP_004236876.1 NZ_CP128435:c2427603-2427301 [Morganella morganii subsp. morganii]
MGKSLRQLLAEEKPEVAAAARVQADEILLNIHLAELREKVKKTQVEMAQALGIKQPTVAGMEKPGRDVKLSTLRRYVDAI
GGKLNIDVELPDGTHYMFRV

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB J7TDD0

References