Detailed information of TA system TA284545

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 2778515..2779094
• Replicon: chromosome
• Accession: NZ_CP128389
• Organism: Staphylococcus aureus strain 21-024

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: QTN91_RS13610
• Protein ID: WP_001025401.1
• Coordinates: 2778515..2778760 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2778729..2779094 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QTN91_RS13555 (QTN91_13555)	2774143..2774757	+	615	WP_000191464.1	hypothetical protein	-
QTN91_RS13560 (QTN91_13560)	2774754..2774900	-	147	WP_001795334.1	hypothetical protein	-
QTN91_RS13565 (QTN91_13565)	2775130..2775714	-	585	WP_000825948.1	hypothetical protein	-
QTN91_RS13570 (QTN91_13570)	2775732..2776193	-	462	WP_031794911.1	toxin	-
QTN91_RS13575 (QTN91_13575)	2776206..2776529	-	324	WP_001260487.1	helix-turn-helix transcriptional regulator	-
QTN91_RS13580 (QTN91_13580)	2776693..2776941	+	249	WP_000272859.1	helix-turn-helix transcriptional regulator	-
QTN91_RS13585 (QTN91_13585)	2776954..2777397	+	444	WP_000435357.1	hypothetical protein	-
QTN91_RS13590 (QTN91_13590)	2777412..2777561	+	150	WP_000771849.1	hypothetical protein	-
QTN91_RS13595 (QTN91_13595)	2777602..2777814	-	213	WP_000362644.1	hypothetical protein	-
QTN91_RS13600 (QTN91_13600)	2777884..2778081	+	198	WP_001148860.1	hypothetical protein	-
QTN91_RS13605 (QTN91_13605)	2778068..2778448	-	381	WP_000773059.1	DUF2513 domain-containing protein	-
QTN91_RS13610 (QTN91_13610)	2778515..2778760	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
QTN91_RS13615 (QTN91_13615)	2778729..2779094	-	366	WP_001128433.1	hypothetical protein	Antitoxin
QTN91_RS13620 (QTN91_13620)	2779149..2779364	+	216	WP_001097552.1	hypothetical protein	-
QTN91_RS13625 (QTN91_13625)	2779391..2779654	+	264	WP_001596347.1	helix-turn-helix domain-containing protein	-
QTN91_RS13630 (QTN91_13630)	2779667..2779828	+	162	WP_001285948.1	DUF1270 domain-containing protein	-
QTN91_RS13635 (QTN91_13635)	2779907..2780230	+	324	WP_000174994.1	hypothetical protein	-
QTN91_RS13640 (QTN91_13640)	2780245..2780607	+	363	WP_000985976.1	hypothetical protein	-
QTN91_RS13645 (QTN91_13645)	2780604..2781770	+	1167	WP_289213739.1	DUF2800 domain-containing protein	-
QTN91_RS13650 (QTN91_13650)	2781797..2782351	+	555	WP_000647288.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T284545 WP_001025401.1 NZ_CP128389:2778515-2778760 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 366 bp

>AT284545 NZ_CP128389:c2779094-2778729 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTCCGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin