Detailed information of TA system TA284534

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 2790307..2790886
• Replicon: chromosome
• Accession: NZ_CP128388
• Organism: Staphylococcus aureus strain 21-074

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: QTN92_RS13615
• Protein ID: WP_001025401.1
• Coordinates: 2790307..2790552 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2790521..2790886 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QTN92_RS13570 (QTN92_13570)	2786311..2786925	+	615	WP_000191459.1	hypothetical protein	-
QTN92_RS13575 (QTN92_13575)	2786922..2787068	-	147	WP_078098719.1	hypothetical protein	-
QTN92_RS13580 (QTN92_13580)	2787298..2787882	-	585	WP_000825948.1	hypothetical protein	-
QTN92_RS13585 (QTN92_13585)	2787900..2788361	-	462	WP_000525004.1	hypothetical protein	-
QTN92_RS13590 (QTN92_13590)	2788374..2788697	-	324	WP_282803398.1	helix-turn-helix transcriptional regulator	-
QTN92_RS13595 (QTN92_13595)	2788862..2789110	+	249	WP_282803397.1	helix-turn-helix transcriptional regulator	-
QTN92_RS13600 (QTN92_13600)	2789126..2789869	+	744	WP_282803396.1	phage antirepressor KilAC domain-containing protein	-
QTN92_RS13605 (QTN92_13605)	2789909..2790052	+	144	WP_031797335.1	hypothetical protein	-
QTN92_RS13610 (QTN92_13610)	2790042..2790251	-	210	WP_000642492.1	hypothetical protein	-
QTN92_RS13615 (QTN92_13615)	2790307..2790552	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
QTN92_RS13620 (QTN92_13620)	2790521..2790886	-	366	WP_016170627.1	hypothetical protein	Antitoxin
QTN92_RS13625 (QTN92_13625)	2790941..2791156	+	216	WP_001097552.1	hypothetical protein	-
QTN92_RS13630 (QTN92_13630)	2791181..2791444	+	264	WP_016187436.1	helix-turn-helix domain-containing protein	-
QTN92_RS13635 (QTN92_13635)	2791457..2791618	+	162	WP_001285948.1	DUF1270 domain-containing protein	-
QTN92_RS13640 (QTN92_13640)	2791697..2792020	+	324	WP_000174994.1	hypothetical protein	-
QTN92_RS13645 (QTN92_13645)	2792035..2792397	+	363	WP_000985976.1	hypothetical protein	-
QTN92_RS13650 (QTN92_13650)	2792394..2793560	+	1167	WP_015581855.1	DUF2800 domain-containing protein	-
QTN92_RS13655 (QTN92_13655)	2793586..2794143	+	558	WP_000645045.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T284534 WP_001025401.1 NZ_CP128388:2790307-2790552 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 366 bp

>AT284534 NZ_CP128388:c2790886-2790521 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTACGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin