Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2215108..2215808 Replicon chromosome
Accession NC_019382
Organism Bordetella bronchiseptica 253

Toxin (Protein)


Gene name mqsR Uniprot ID A0A0H3LPJ8
Locus tag BN112_RS10580 Protein ID WP_003809515.1
Coordinates 2215512..2215808 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID Q7VY40
Locus tag BN112_RS10575 Protein ID WP_003809516.1
Coordinates 2215108..2215509 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BN112_RS10545 2210281..2211315 - 1035 WP_015064286.1 amino acid ABC transporter substrate-binding protein -
BN112_RS10550 2211452..2212489 - 1038 WP_003809529.1 threonylcarbamoyl-AMP synthase -
BN112_RS10555 2212509..2213699 - 1191 WP_003809527.1 5-(carboxyamino)imidazole ribonucleotide synthase -
BN112_RS10560 2213702..2214217 - 516 WP_019247930.1 5-(carboxyamino)imidazole ribonucleotide mutase -
BN112_RS10565 2214365..2214844 - 480 WP_003809523.1 disulfide bond formation protein B -
BN112_RS10570 2214852..2215088 - 237 WP_003809519.1 hypothetical protein -
BN112_RS10575 2215108..2215509 - 402 WP_003809516.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
BN112_RS10580 2215512..2215808 - 297 WP_003809515.1 type II toxin-antitoxin system MqsR family toxin Toxin
BN112_RS10585 2216091..2216972 - 882 WP_003809513.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
BN112_RS10590 2217198..2217644 + 447 WP_015064287.1 GFA family protein -
BN112_RS10595 2217729..2218793 - 1065 WP_015064288.1 fructose-bisphosphate aldolase class II -
BN112_RS10600 2218969..2219511 - 543 WP_015064289.1 MOSC domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Antitoxin MqsA/HigA-2

(1-131)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10608.50 Da        Isoelectric Point: 7.9291

>T28453 WP_003809515.1 NC_019382:c2215808-2215512 [Bordetella bronchiseptica 253]
MEKGTPHCKLPALKALVHAGQVRATYSALSGAAALGLDFSAMVEIVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAV
YLKLTVLDGVLIVSFKEL

Download         Length: 297 bp

>T28453 NC_019382:c2215808-2215512 [Bordetella bronchiseptica 253]
ATGGAAAAGGGAACACCGCACTGCAAGCTGCCGGCGCTCAAGGCGCTGGTCCATGCAGGCCAGGTCCGAGCCACGTATTC
CGCCTTGTCCGGCGCGGCGGCGCTGGGGCTGGATTTCAGCGCCATGGTCGAAATCGTGCTTGCACTGACACCGCGGGATT
TCCACAAAAGCATGACTACCCATGCCGACCATCGCATTTGGCAGGACGTCTATTGCCCAGTGACAGCGATGGGTGCCGTC
TACCTGAAGCTGACGGTCCTCGACGGCGTGCTGATCGTGTCGTTCAAGGAGTTGTGA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14528.70 Da        Isoelectric Point: 8.5005

>AT28453 WP_003809516.1 NC_019382:c2215509-2215108 [Bordetella bronchiseptica 253]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Download         Length: 402 bp

>AT28453 NC_019382:c2215509-2215108 [Bordetella bronchiseptica 253]
ATGAAGTGTCCCGTATGCGGAGCGGCCGCGCTGGCGCGTGATACTCGCGATGTGCCCTATAGCTACAAGGGCGAGACCAT
CACCATTGCGGCGGTGACGGGCGACTGGTGTCCGGCATGCGGCGAGAACGTGCTCGATGGCGCCGAATCGGCGCGGGTGA
GCGAGGCCATGCTGGCTTTCAACCGCCTGGTCAACGCCCGCCGCGTCGACCCCGGGTTCATCGTGCGGGTGCGCAGGAAG
CTGGGGTTGGACCAGCGCGAAGCCGCGGCGCTGTTCGGCGGCGGCACCAATGCGTTCTCGCGTTACGAGAACGGCAAGAC
GCGCCCGCCCCTGGCGCTGGTGAAGCTGCTCAGGCTGCTGGATCGCCATCCGGAGCTGCTGGAGGAAGTCCGTGCGGATT
GA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3LPJ8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3LKS6

References