Detailed information of TA system TA284523

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): TMCS/-
• Location: 2790293..2790872
• Replicon: chromosome
• Accession: NZ_CP128387
• Organism: Staphylococcus aureus strain 22-042

Toxin (Protein)

• Gene name: MW1434
• Uniprot ID: A0A4P7P609
• Locus tag: QTN90_RS13675
• Protein ID: WP_001025401.1
• Coordinates: 2790293..2790538 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2790507..2790872 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QTN90_RS13630 (QTN90_13630)	2786297..2786911	+	615	WP_000191459.1	hypothetical protein	-
QTN90_RS13635 (QTN90_13635)	2786908..2787054	-	147	WP_078098719.1	hypothetical protein	-
QTN90_RS13640 (QTN90_13640)	2787284..2787868	-	585	WP_000825948.1	hypothetical protein	-
QTN90_RS13645 (QTN90_13645)	2787886..2788347	-	462	WP_000525004.1	hypothetical protein	-
QTN90_RS13650 (QTN90_13650)	2788360..2788683	-	324	WP_282803398.1	helix-turn-helix transcriptional regulator	-
QTN90_RS13655 (QTN90_13655)	2788848..2789096	+	249	WP_282803397.1	helix-turn-helix transcriptional regulator	-
QTN90_RS13660 (QTN90_13660)	2789112..2789855	+	744	WP_282803396.1	phage antirepressor KilAC domain-containing protein	-
QTN90_RS13665 (QTN90_13665)	2789895..2790038	+	144	WP_031797335.1	hypothetical protein	-
QTN90_RS13670 (QTN90_13670)	2790028..2790237	-	210	WP_000642492.1	hypothetical protein	-
QTN90_RS13675 (QTN90_13675)	2790293..2790538	+	246	WP_001025401.1	DUF2829 domain-containing protein	Toxin
QTN90_RS13680 (QTN90_13680)	2790507..2790872	-	366	WP_016170627.1	hypothetical protein	Antitoxin
QTN90_RS13685 (QTN90_13685)	2790927..2791142	+	216	WP_001097552.1	hypothetical protein	-
QTN90_RS13690 (QTN90_13690)	2791167..2791430	+	264	WP_016187436.1	helix-turn-helix domain-containing protein	-
QTN90_RS13695 (QTN90_13695)	2791443..2791604	+	162	WP_001285948.1	DUF1270 domain-containing protein	-
QTN90_RS13700 (QTN90_13700)	2791683..2792006	+	324	WP_000174994.1	hypothetical protein	-
QTN90_RS13705 (QTN90_13705)	2792021..2792383	+	363	WP_000985976.1	hypothetical protein	-
QTN90_RS13710 (QTN90_13710)	2792380..2793546	+	1167	WP_015581855.1	DUF2800 domain-containing protein	-
QTN90_RS13715 (QTN90_13715)	2793572..2794129	+	558	WP_000645045.1	DUF2815 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF2829 (2-69)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 9468.72 Da
• Isoelectric Point: 5.7783

>T284523 WP_001025401.1 NZ_CP128387:2790293-2790538 [Staphylococcus aureus]
MNIQEATKIATKNLVSMTRKDWKESHRTKILPTNDSFLQCIISNSDGTNLIRYWQPSADDLMANDWEVINPTRDQELLKQ
F

Nucleotide

• Length: 246 bp

Antitoxin

Nucleotide

• Length: 366 bp

>AT284523 NZ_CP128387:c2790872-2790507 [Staphylococcus aureus]
ATGCCCTTGATATCTGATGAATTTGATACACTTACTAAAGACCAACAATATATCTTGTACGTACTCTACAAAGATTATTT
AGAATGTGTAAAGTTAGGTTCGGTTAAATTAACCTGCAATAATTTTGGAAGTGCTAAAGATATACATACAAAGTATTTTC
AAAAACTACATTTCGAAGATGTAAAATACGATTTAAATAAACTTAAAAACTCTGGGTTCCTAAACGGCGTGTATGCTAGT
AACACTATTTATCATGTAACAATTTCAGACAAGACTGTTGTTTACTTTGAAAATGAGTTTAAAAACAATTTAAAAAGTAT
CATTGATAGCATTTCTAAAATTGCTTCAATAATTCCTGGTCTCTAG

Structures

Toxin

• AlphaFold DB: A0A4P7P609

Antitoxin