Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4566084..4566686 Replicon chromosome
Accession NZ_CP128261
Organism Salmonella enterica subsp. enterica serovar Heidelberg isolate FT3-7B

Toxin (Protein)


Gene name higB Uniprot ID M7S4R6
Locus tag QR684_RS22150 Protein ID WP_001159635.1
Coordinates 4566375..4566686 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QR684_RS22145 Protein ID WP_000362050.1
Coordinates 4566084..4566374 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QR684_RS22130 (4563577) 4563577..4564479 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
QR684_RS22135 (4564476) 4564476..4565111 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
QR684_RS22140 (4565108) 4565108..4566037 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
QR684_RS22145 (4566084) 4566084..4566374 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
QR684_RS22150 (4566375) 4566375..4566686 - 312 WP_001159635.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
QR684_RS22155 (4566904) 4566904..4567833 + 930 WP_001127705.1 alpha/beta hydrolase -
QR684_RS22160 (4567919) 4567919..4568230 + 312 WP_000558163.1 type II toxin-antitoxin system HigB family toxin -
QR684_RS22165 (4568227) 4568227..4568673 + 447 WP_001259012.1 type II toxin-antitoxin system HigA family antitoxin -
QR684_RS22170 (4568688) 4568688..4569629 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
QR684_RS22175 (4569674) 4569674..4570111 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
QR684_RS22180 (4570108) 4570108..4570980 - 873 WP_000921423.1 virulence factor BrkB family protein -
QR684_RS22185 (4570974) 4570974..4571573 - 600 WP_000965702.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12340.30 Da        Isoelectric Point: 9.4460

>T284506 WP_001159635.1 NZ_CP128261:c4566686-4566375 [Salmonella enterica subsp. enterica serovar Heidelberg]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT284506 WP_000362050.1 NZ_CP128261:c4566374-4566084 [Salmonella enterica subsp. enterica serovar Heidelberg]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V2JK97

Antitoxin

Source ID Structure

References