Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4975299..4975901 Replicon chromosome
Accession NZ_CP128255
Organism Escherichia coli strain T309.Ta3

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag QRX22_RS24355 Protein ID WP_000897302.1
Coordinates 4975590..4975901 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QRX22_RS24350 Protein ID WP_000356397.1
Coordinates 4975299..4975589 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRX22_RS24325 (4971372) 4971372..4972274 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
QRX22_RS24330 (4972271) 4972271..4972906 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
QRX22_RS24335 (4972903) 4972903..4973832 + 930 WP_000027720.1 formate dehydrogenase accessory protein FdhE -
QRX22_RS24340 (4974048) 4974048..4974266 - 219 WP_001314326.1 CopG family transcriptional regulator -
QRX22_RS24345 (4974662) 4974662..4974940 - 279 WP_001296612.1 hypothetical protein -
QRX22_RS24350 (4975299) 4975299..4975589 - 291 WP_000356397.1 NadS family protein Antitoxin
QRX22_RS24355 (4975590) 4975590..4975901 - 312 WP_000897302.1 hypothetical protein Toxin
QRX22_RS24360 (4976130) 4976130..4977038 + 909 WP_001331553.1 alpha/beta hydrolase -
QRX22_RS24365 (4977102) 4977102..4978043 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
QRX22_RS24370 (4978088) 4978088..4978525 - 438 WP_021531734.1 D-aminoacyl-tRNA deacylase -
QRX22_RS24375 (4978522) 4978522..4979394 - 873 WP_000920762.1 virulence factor BrkB family protein -
QRX22_RS24380 (4979388) 4979388..4979987 - 600 WP_001314324.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T284479 WP_000897302.1 NZ_CP128255:c4975901-4975590 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT284479 WP_000356397.1 NZ_CP128255:c4975589-4975299 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References