Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2680214..2680776 Replicon chromosome
Accession NZ_CP128255
Organism Escherichia coli strain T309.Ta3

Toxin (Protein)


Gene name higB Uniprot ID S1Q1V8
Locus tag QRX22_RS13080 Protein ID WP_000605675.1
Coordinates 2680214..2680492 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QRX22_RS13085 Protein ID WP_033559508.1
Coordinates 2680492..2680776 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRX22_RS13055 (2675800) 2675800..2676231 - 432 WP_000152305.1 peroxiredoxin OsmC -
QRX22_RS13060 (2676576) 2676576..2676791 + 216 WP_000495766.1 biofilm-dependent modulation protein -
QRX22_RS13065 (2676893) 2676893..2677030 + 138 WP_000841554.1 stationary-phase-induced ribosome-associated protein -
QRX22_RS13070 (2677187) 2677187..2678884 + 1698 WP_000433460.1 malate dehydrogenase -
QRX22_RS13075 (2679018) 2679018..2680028 + 1011 WP_000642412.1 alcohol dehydrogenase AdhP -
QRX22_RS13080 (2680214) 2680214..2680492 + 279 WP_000605675.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QRX22_RS13085 (2680492) 2680492..2680776 + 285 WP_033559508.1 HigA family addiction module antitoxin Antitoxin
QRX22_RS13090 (2681005) 2681005..2681658 - 654 WP_000045647.1 formate dehydrogenase-N subunit gamma -
QRX22_RS13095 (2681651) 2681651..2682535 - 885 WP_001240584.1 formate dehydrogenase N subunit beta -
QRX22_RS13100 (2682548) 2682548..2685595 - 3048 WP_011478186.1 formate dehydrogenase-N subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(4-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-64)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10537.16 Da        Isoelectric Point: 7.3206

>T284469 WP_000605675.1 NZ_CP128255:2680214-2680492 [Escherichia coli]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAACCLADIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT284469 WP_033559508.1 NZ_CP128255:2680492-2680776 [Escherichia coli]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVLGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1Q1V8

Antitoxin

Source ID Structure

References