Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1996688..1997190 Replicon chromosome
Accession NZ_CP128255
Organism Escherichia coli strain T309.Ta3

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag QRX22_RS09670 Protein ID WP_000767829.1
Coordinates 1996936..1997190 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag QRX22_RS09665 Protein ID WP_032298579.1
Coordinates 1996688..1996939 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRX22_RS09640 (1991866) 1991866..1992933 - 1068 WP_033559267.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
QRX22_RS09645 (1992933) 1992933..1994003 - 1071 WP_033559268.1 histidinol-phosphate transaminase -
QRX22_RS09650 (1994000) 1994000..1995304 - 1305 WP_001445483.1 histidinol dehydrogenase -
QRX22_RS09655 (1995310) 1995310..1996209 - 900 WP_000131779.1 ATP phosphoribosyltransferase -
QRX22_RS09660 (1996355) 1996355..1996405 - 51 WP_001364200.1 his operon leader peptide -
QRX22_RS09665 (1996688) 1996688..1996939 + 252 WP_032298579.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
QRX22_RS09670 (1996936) 1996936..1997190 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
QRX22_RS09675 (1997273) 1997273..1998097 + 825 WP_000754740.1 SDR family oxidoreductase -
QRX22_RS09680 (1998143) 1998143..1999072 + 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
QRX22_RS09685 (1999287) 1999287..1999349 + 63 WP_010723108.1 membrane protein YoeI -
QRX22_RS09690 (1999339) 1999339..2000697 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T284464 WP_000767829.1 NZ_CP128255:1996936-1997190 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9254.53 Da        Isoelectric Point: 4.5821

>AT284464 WP_032298579.1 NZ_CP128255:1996688-1996939 [Escherichia coli]
MRTISYSEACQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure

References