Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 621377..622176 Replicon chromosome
Accession NZ_CP128255
Organism Escherichia coli strain T309.Ta3

Toxin (Protein)


Gene name yhaV Uniprot ID Q8FDB4
Locus tag QRX22_RS03075 Protein ID WP_000347252.1
Coordinates 621377..621841 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag QRX22_RS03080 Protein ID WP_001296435.1
Coordinates 621841..622176 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRX22_RS03045 (616378) 616378..616812 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
QRX22_RS03050 (616830) 616830..617708 - 879 WP_001298314.1 PTS N-acetylgalactosamine transporter subunit IID -
QRX22_RS03055 (617698) 617698..618477 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
QRX22_RS03060 (618488) 618488..618961 - 474 WP_001298322.1 PTS N-acetylgalactosamine transporter subunit IIB -
QRX22_RS03065 (618984) 618984..620264 - 1281 WP_000681930.1 tagatose-bisphosphate aldolase subunit KbaZ -
QRX22_RS03070 (620513) 620513..621322 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QRX22_RS03075 (621377) 621377..621841 - 465 WP_000347252.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QRX22_RS03080 (621841) 621841..622176 - 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QRX22_RS03085 (622325) 622325..623896 - 1572 WP_021531624.1 galactarate dehydratase -
QRX22_RS03090 (624271) 624271..625605 + 1335 WP_000979025.1 galactarate/glucarate/glycerate transporter GarP -
QRX22_RS03095 (625621) 625621..626391 + 771 WP_033559498.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17750.11 Da        Isoelectric Point: 9.4947

>T284460 WP_000347252.1 NZ_CP128255:c621841-621377 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEESH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT284460 WP_001296435.1 NZ_CP128255:c622176-621841 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q8FDB4

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References