Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 956727..957327 Replicon chromosome
Accession NZ_CP128233
Organism Paralcaligenes sp. CC-YST667

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag N7E01_RS05035 Protein ID WP_128355399.1
Coordinates 956727..957038 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag N7E01_RS05040 Protein ID WP_128355400.1
Coordinates 957040..957327 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N7E01_RS05015 (N7E01_05015) 952505..953584 - 1080 WP_289174830.1 peptide chain release factor 1 -
N7E01_RS05020 (N7E01_05020) 953673..954947 - 1275 WP_289174831.1 glutamyl-tRNA reductase -
N7E01_RS05030 (N7E01_05030) 955410..956666 + 1257 WP_289174832.1 integrase arm-type DNA-binding domain-containing protein -
N7E01_RS05035 (N7E01_05035) 956727..957038 + 312 WP_128355399.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N7E01_RS05040 (N7E01_05040) 957040..957327 + 288 WP_128355400.1 NadS family protein Antitoxin
N7E01_RS05045 (N7E01_05045) 957403..957693 + 291 WP_128355401.1 hypothetical protein -
N7E01_RS05050 (N7E01_05050) 957745..958416 + 672 WP_128355402.1 TrbM/KikA/MpfK family conjugal transfer protein -
N7E01_RS05055 (N7E01_05055) 958427..959092 + 666 WP_128355403.1 lytic transglycosylase domain-containing protein -
N7E01_RS05060 (N7E01_05060) 959175..959495 + 321 WP_128355404.1 TrbC/VirB2 family protein -
N7E01_RS05065 (N7E01_05065) 959499..959927 + 429 WP_289174833.1 VirB3 family type IV secretion system protein -
N7E01_RS05070 (N7E01_05070) 959830..961476 + 1647 WP_228255706.1 hypothetical protein -
N7E01_RS05075 (N7E01_05075) 961383..962273 + 891 WP_289174834.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element dfrA12 / aadA2 / aac(6')-IIa / blaOXA-17 / qacE / floR / tet(G) / sul1 - 955353..1015847 60494


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(42-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-79)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11666.54 Da        Isoelectric Point: 5.8505

>T284446 WP_128355399.1 NZ_CP128233:956727-957038 [Paralcaligenes sp. CC-YST667]
MEFIETPLFTRQIVDLLPDDDYAELQQILAANPRRGDLIPSGGGIRKVRHARPGMGKSGGIRVIYYWITAEDQIMMLLAY
PKSKQENLTPAQIEELRALVKDL

Download         Length: 312 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10415.93 Da        Isoelectric Point: 10.5848

>AT284446 WP_128355400.1 NZ_CP128233:957040-957327 [Paralcaligenes sp. CC-YST667]
MDTELFEDLKESLRQAKAIRAGELEGRRTTVSPIDVRAVRESTKLSQGEFAAAINVSVRTLQNWEQHRRSPTGPAAALLK
VMAAAPATVIKALHH

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References