Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2787347..2788040 Replicon chromosome
Accession NZ_CP128218
Organism Escherichia coli strain TG1

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag QSI84_RS13695 Protein ID WP_000415584.1
Coordinates 2787744..2788040 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag QSI84_RS13690 Protein ID WP_000650107.1
Coordinates 2787347..2787742 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QSI84_RS13680 (2783211) 2783211..2785469 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
QSI84_RS13685 (2785607) 2785607..2787214 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
QSI84_RS13690 (2787347) 2787347..2787742 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
QSI84_RS13695 (2787744) 2787744..2788040 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
QSI84_RS13700 (2788245) 2788245..2788727 - 483 WP_000183505.1 GyrI-like domain-containing protein -
QSI84_RS13705 (2788780) 2788780..2789172 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
QSI84_RS13710 (2789324) 2789324..2789983 + 660 WP_001221495.1 quorum sensing response regulator transcription factor QseB -
QSI84_RS13715 (2789980) 2789980..2791329 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
QSI84_RS13720 (2791375) 2791375..2791707 - 333 WP_000917684.1 DUF2645 family protein -
QSI84_RS13725 (2792026) 2792026..2792607 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
QSI84_RS13730 (2792638) 2792638..2792952 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T284428 WP_000415584.1 NZ_CP128218:c2788040-2787744 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT284428 WP_000650107.1 NZ_CP128218:c2787742-2787347 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References