284389

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 46288..47015 Replicon plasmid pVir_KP0714
Accession NZ_CP128192
Organism Klebsiella pneumoniae strain KP0714

Toxin (Protein)


Gene name higB Uniprot ID A0A5Q9LNL2
Locus tag QSG82_RS27520 Protein ID WP_004118600.1
Coordinates 46288..46599 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID V0AHC4
Locus tag QSG82_RS27525 Protein ID WP_000990392.1
Coordinates 46596..47015 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QSG82_RS27500 (QSG82_27500) 42802..43521 + 720 WP_001102107.1 (Fe-S)-binding protein -
QSG82_RS27505 (QSG82_27505) 43532..44959 + 1428 WP_000023895.1 LutB/LldF family L-lactate oxidation iron-sulfur protein -
QSG82_RS27510 (QSG82_27510) 44952..45647 + 696 WP_004118595.1 lactate utilization protein C -
QSG82_RS27515 (QSG82_27515) 45697..46077 - 381 Protein_47 gluconate permease -
QSG82_RS27520 (QSG82_27520) 46288..46599 + 312 WP_004118600.1 type II toxin-antitoxin system HigB family toxin Toxin
QSG82_RS27525 (QSG82_27525) 46596..47015 + 420 WP_000990392.1 helix-turn-helix domain-containing protein Antitoxin
QSG82_RS27530 (QSG82_27530) 47052..48254 - 1203 WP_003031541.1 hypothetical protein -
QSG82_RS27535 (QSG82_27535) 48247..48576 - 330 WP_004118613.1 hypothetical protein -
QSG82_RS27540 (QSG82_27540) 48573..49232 - 660 WP_000078540.1 hypothetical protein -
QSG82_RS27545 (QSG82_27545) 49656..50012 - 357 WP_077253206.1 Ref family recombination enhancement nuclease -
QSG82_RS27550 (QSG82_27550) 50132..50272 - 141 WP_004118614.1 hypothetical protein -
QSG82_RS27555 (QSG82_27555) 50565..50918 + 354 WP_001114073.1 As(III)-sensing metalloregulatory transcriptional repressor ArsR -
QSG82_RS27560 (QSG82_27560) 50966..51328 + 363 WP_020324593.1 arsenite efflux transporter metallochaperone ArsD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid aac(6')-Ib-cr / blaOXA-1 / catB3 / ARR-3 / qacE / sul1 rmpA / iutA / iucD / iucC / iucB / iucA 1..254123 254123


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(83-136)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12386.14 Da        Isoelectric Point: 10.0935

>T284389 WP_004118600.1 NZ_CP128192:46288-46599 [Klebsiella pneumoniae]
MHIVSRAPFDTATRQFPNQAAALDDVYRTLKRENYTSPDEMKKRFASLDRMKYREKWWVIDVGGGNLRVMFFADFERGKI
FIKHITTHAEYDKLTDFYRRTKE

Download         Length: 312 bp

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15534.71 Da        Isoelectric Point: 4.4702

>AT284389 WP_000990392.1 NZ_CP128192:46596-47015 [Klebsiella pneumoniae]
MMYTDAIQAANSLVSIVPLLGGNASRKDYEDALTLVEYLVEHEPDHPLVDMLVAKIAQYEDEAEEFAEFNDRIAALPSGV
ALLRVLMDQHKLTQSDFEEEIGKKSLVSRILNGTRSLTLDHMKALARRFNIPPSSFMDA

Download         Length: 420 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Q9LNL2

Antitoxin

Source ID Structure
AlphaFold DB V0AHC4

References