Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 795565..796340 Replicon chromosome
Accession NZ_CP128191
Organism Klebsiella pneumoniae strain KP0714

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag QSG82_RS04065 Protein ID WP_004150910.1
Coordinates 795855..796340 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag QSG82_RS04060 Protein ID WP_004150912.1
Coordinates 795565..795858 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QSG82_RS04040 (QSG82_04040) 790773..791375 - 603 WP_062954968.1 short chain dehydrogenase -
QSG82_RS04045 (QSG82_04045) 791473..792384 + 912 WP_004188550.1 LysR family transcriptional regulator -
QSG82_RS04050 (QSG82_04050) 792385..793533 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
QSG82_RS04055 (QSG82_04055) 793544..794920 - 1377 WP_004217775.1 cystathionine beta-synthase -
QSG82_RS04060 (QSG82_04060) 795565..795858 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
QSG82_RS04065 (QSG82_04065) 795855..796340 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
QSG82_RS04070 (QSG82_04070) 797044..797637 + 594 WP_004188553.1 hypothetical protein -
QSG82_RS04075 (QSG82_04075) 797734..797950 + 217 Protein_803 transposase -
QSG82_RS04080 (QSG82_04080) 798556..799428 + 873 WP_004188557.1 ParA family protein -
QSG82_RS04085 (QSG82_04085) 799428..799811 + 384 WP_004150906.1 hypothetical protein -
QSG82_RS04090 (QSG82_04090) 799804..801171 + 1368 WP_004150905.1 SPI-7-type island replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 797734..797886 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T284377 WP_004150910.1 NZ_CP128191:795855-796340 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT284377 WP_004150912.1 NZ_CP128191:795565-795858 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References