Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3320226..3320886 Replicon chromosome
Accession NZ_CP127881
Organism Serratia marcescens strain ELP1.10

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag QRD25_RS15890 Protein ID WP_031300708.1
Coordinates 3320533..3320886 (-) Length 118 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QRD25_RS15885 Protein ID WP_049186895.1
Coordinates 3320226..3320528 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRD25_RS15860 (QRD25_15865) 3315606..3316334 - 729 WP_239664295.1 SDR family oxidoreductase -
QRD25_RS15865 (QRD25_15870) 3316377..3317012 - 636 WP_004935489.1 SDR family oxidoreductase -
QRD25_RS15870 (QRD25_15875) 3317028..3317963 - 936 WP_049187877.1 alpha/beta hydrolase -
QRD25_RS15875 (QRD25_15880) 3317963..3318883 - 921 WP_031300707.1 alpha/beta hydrolase -
QRD25_RS15880 (QRD25_15885) 3319022..3319930 + 909 WP_004935498.1 LysR family transcriptional regulator -
QRD25_RS15885 (QRD25_15890) 3320226..3320528 - 303 WP_049186895.1 XRE family transcriptional regulator Antitoxin
QRD25_RS15890 (QRD25_15895) 3320533..3320886 - 354 WP_031300708.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QRD25_RS15895 (QRD25_15900) 3321325..3322620 + 1296 WP_197753346.1 tricarballylate/proton symporter TcuC -
QRD25_RS15900 (QRD25_15905) 3322647..3323453 + 807 WP_049186899.1 substrate-binding domain-containing protein -
QRD25_RS15905 (QRD25_15910) 3323428..3324327 - 900 WP_286093451.1 LysR family transcriptional regulator -
QRD25_RS15910 (QRD25_15915) 3324431..3324796 - 366 WP_004935528.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3314037..3339594 25557


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(18-89)


Sequences

Toxin        


Download         Length: 118 a.a.        Molecular weight: 13609.61 Da        Isoelectric Point: 9.0493

>T284339 WP_031300708.1 NZ_CP127881:c3320886-3320533 [Serratia marcescens]
VWEIKTTDAFDHWFRSLSDADRACVLAALMVLREKGPGLPRPYADTVKGSRYSNMKELRIQSRGEPLRAFFAFDPYRIGM
VLCAGNKAGDEKRFYDRMLQIADREFTNWLNTLKEKE

Download         Length: 354 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11156.99 Da        Isoelectric Point: 5.1992

>AT284339 WP_049186895.1 NZ_CP127881:c3320528-3320226 [Serratia marcescens]
MGRTLEQLIAEEKPEVVAEAQAMATDIMLNIHLAELREKVQKTQVEMAQALGIRQPTVAVMEKPGRDLKLSSLKRYVEAA
GGKLRLDIELPDGSHYEFVL

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References