Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 4946726..4947330 Replicon chromosome
Accession NZ_CP127872
Organism Pseudomonas asiatica strain RYYT.1b

Toxin (Protein)


Gene name higB Uniprot ID A0A1L5PVG8
Locus tag QQ994_RS22300 Protein ID WP_075046186.1
Coordinates 4946726..4947046 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1L5PVK4
Locus tag QQ994_RS22305 Protein ID WP_075046187.1
Coordinates 4947043..4947330 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQ994_RS22275 (QQ994_22275) 4942232..4942444 + 213 WP_015271611.1 cysteine-rich CWC family protein -
QQ994_RS22280 (QQ994_22280) 4942454..4943146 + 693 WP_075046183.1 pseudouridine synthase -
QQ994_RS22285 (QQ994_22285) 4943595..4944482 + 888 WP_075046184.1 (R)-3-hydroxydecanoyl-ACP:CoA transacylase -
QQ994_RS22295 (QQ994_22295) 4944832..4946538 + 1707 WP_075046185.1 SulP family inorganic anion transporter -
QQ994_RS22300 (QQ994_22300) 4946726..4947046 + 321 WP_075046186.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QQ994_RS22305 (QQ994_22305) 4947043..4947330 + 288 WP_075046187.1 NadS family protein Antitoxin
QQ994_RS22310 (QQ994_22310) 4947413..4948480 - 1068 WP_286100490.1 glycerophosphodiester phosphodiesterase family protein -
QQ994_RS22315 (QQ994_22315) 4948720..4949730 + 1011 WP_075046189.1 DUF4917 family protein -
QQ994_RS22320 (QQ994_22320) 4949883..4950926 - 1044 WP_075046190.1 tetratricopeptide repeat protein -
QQ994_RS22325 (QQ994_22325) 4950928..4951896 - 969 WP_075047036.1 type II secretion system F family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(43-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(35-87)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12232.08 Da        Isoelectric Point: 10.1916

>T284318 WP_075046186.1 NZ_CP127872:4946726-4947046 [Pseudomonas asiatica]
MLFTETTLFTKRVRELLDDDTYRLLQVRLMASPETGDLIEGTGGLRKIRVPANGHGKRGGARVIYYHFISRSQIAMLYIY
GKNEQPDLSSEQRKALKSIIEHWRHA

Download         Length: 321 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10832.42 Da        Isoelectric Point: 8.0584

>AT284318 WP_075046187.1 NZ_CP127872:4947043-4947330 [Pseudomonas asiatica]
MNRFFDELMESVQQMDDIVQGKCAPSREFAIDALQVRSIRRATGLSQVRFAEMIDVQVATLRNWEQGRREPTGPAKALLR
AIRNDPDHVLKALAH

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L5PVG8

Antitoxin

Source ID Structure
AlphaFold DB A0A1L5PVK4

References