Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 746038..746731 Replicon chromosome
Accession NZ_CP127848
Organism Escherichia coli strain MB7671

Toxin (Protein)


Gene name mqsR Uniprot ID U9ZN09
Locus tag PJZ59_RS03630 Protein ID WP_000415585.1
Coordinates 746038..746334 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag PJZ59_RS03635 Protein ID WP_000650107.1
Coordinates 746336..746731 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PJZ59_RS03595 (741172) 741172..741651 + 480 WP_000065332.1 Hcp family type VI secretion system effector -
PJZ59_RS03600 (741654) 741654..742364 + 711 WP_000834030.1 hypothetical protein -
PJZ59_RS03605 (742371) 742371..742703 + 333 WP_000914690.1 DUF2645 family protein -
PJZ59_RS03610 (742749) 742749..744098 - 1350 WP_000673358.1 quorum sensing histidine kinase QseC -
PJZ59_RS03615 (744095) 744095..744754 - 660 WP_001221502.1 quorum sensing response regulator transcription factor QseB -
PJZ59_RS03620 (744906) 744906..745298 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
PJZ59_RS03625 (745351) 745351..745833 + 483 WP_000183505.1 GyrI-like domain-containing protein -
PJZ59_RS03630 (746038) 746038..746334 + 297 WP_000415585.1 type II toxin-antitoxin system toxin MqsR Toxin
PJZ59_RS03635 (746336) 746336..746731 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
PJZ59_RS03640 (746864) 746864..748471 + 1608 WP_001375094.1 ABC transporter substrate-binding protein -
PJZ59_RS03645 (748609) 748609..750867 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(2-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11261.99 Da        Isoelectric Point: 8.9070

>T284278 WP_000415585.1 NZ_CP127848:746038-746334 [Escherichia coli]
MEKRTPHTRLSQVKKLVNTGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT284278 WP_000650107.1 NZ_CP127848:746336-746731 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9ZN09

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References