Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 631723..632522 Replicon chromosome
Accession NZ_CP127848
Organism Escherichia coli strain MB7671

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag PJZ59_RS03075 Protein ID WP_000347251.1
Coordinates 631723..632187 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag PJZ59_RS03080 Protein ID WP_001307405.1
Coordinates 632187..632522 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PJZ59_RS03045 (626724) 626724..627158 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
PJZ59_RS03050 (627176) 627176..628054 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
PJZ59_RS03055 (628044) 628044..628823 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
PJZ59_RS03060 (628834) 628834..629307 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
PJZ59_RS03065 (629330) 629330..630610 - 1281 WP_000681903.1 tagatose-bisphosphate aldolase subunit KbaZ -
PJZ59_RS03070 (630859) 630859..631668 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
PJZ59_RS03075 (631723) 631723..632187 - 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
PJZ59_RS03080 (632187) 632187..632522 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
PJZ59_RS03085 (632671) 632671..634242 - 1572 WP_001273761.1 galactarate dehydratase -
PJZ59_RS03090 (634617) 634617..635951 + 1335 WP_000599652.1 galactarate/glucarate/glycerate transporter GarP -
PJZ59_RS03095 (635967) 635967..636737 + 771 WP_001058214.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T284277 WP_000347251.1 NZ_CP127848:c632187-631723 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT284277 WP_001307405.1 NZ_CP127848:c632522-632187 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References