Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3904535..3905132 Replicon chromosome
Accession NZ_CP127839
Organism Klebsiella pneumoniae RYC492

Toxin (Protein)


Gene name higB Uniprot ID A0A9J6S5A1
Locus tag QRF73_RS19015 Protein ID WP_004893639.1
Coordinates 3904815..3905132 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID R4YH91
Locus tag QRF73_RS19010 Protein ID WP_004142561.1
Coordinates 3904535..3904822 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF73_RS18980 (QRF73_18975) 3900615..3900863 + 249 WP_002893037.1 DUF1158 domain-containing protein -
QRF73_RS18985 (QRF73_18980) 3900881..3901222 - 342 WP_002893035.1 RamA family antibiotic efflux transcriptional regulator -
QRF73_RS18990 (QRF73_18985) 3901253..3902368 - 1116 WP_012737592.1 MBL fold metallo-hydrolase -
QRF73_RS18995 (QRF73_18990) 3902548..3903129 + 582 WP_004176968.1 TetR/AcrR family transcriptional regulator -
QRF73_RS19000 (QRF73_18995) 3903129..3903497 + 369 WP_004142557.1 MmcQ/YjbR family DNA-binding protein -
QRF73_RS19005 (QRF73_19000) 3903617..3904270 + 654 WP_004178896.1 oxygen-insensitive NAD(P)H nitroreductase -
QRF73_RS19010 (QRF73_19005) 3904535..3904822 - 288 WP_004142561.1 helix-turn-helix transcriptional regulator Antitoxin
QRF73_RS19015 (QRF73_19010) 3904815..3905132 - 318 WP_004893639.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QRF73_RS19020 (QRF73_19015) 3905317..3906360 - 1044 WP_004893645.1 DUF2157 domain-containing protein -
QRF73_RS19025 (QRF73_19020) 3907026..3907892 - 867 WP_004151823.1 helix-turn-helix transcriptional regulator -
QRF73_RS19030 (QRF73_19025) 3908001..3909428 + 1428 WP_004176980.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12100.35 Da        Isoelectric Point: 11.2767

>T284266 WP_004893639.1 NZ_CP127839:c3905132-3904815 [Klebsiella pneumoniae RYC492]
MFRLVVHVDVKKELQALPSIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQGKTLFLLRVF
VKKTQKTPSSEIRLALKRLEEMRNE

Download         Length: 318 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10771.46 Da        Isoelectric Point: 10.2212

>AT284266 WP_004142561.1 NZ_CP127839:c3904822-3904535 [Klebsiella pneumoniae RYC492]
MSKKIIDWDTLKTELLGQPEVQAAFDAQERQQRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRASLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3DIQ1

References