Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 715244..716019 Replicon chromosome
Accession NZ_CP127839
Organism Klebsiella pneumoniae RYC492

Toxin (Protein)


Gene name TacT2 Uniprot ID B6ZBI6
Locus tag QRF73_RS03540 Protein ID WP_004889762.1
Coordinates 715534..716019 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag QRF73_RS03535 Protein ID WP_004150912.1
Coordinates 715244..715537 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRF73_RS03515 (QRF73_03515) 710453..711055 - 603 WP_004174410.1 short chain dehydrogenase -
QRF73_RS03520 (QRF73_03520) 711153..712064 + 912 WP_017879796.1 LysR family transcriptional regulator -
QRF73_RS03525 (QRF73_03525) 712065..713213 - 1149 WP_004889759.1 PLP-dependent aspartate aminotransferase family protein -
QRF73_RS03530 (QRF73_03530) 713224..714600 - 1377 WP_017879795.1 pyridoxal-phosphate dependent enzyme -
QRF73_RS03535 (QRF73_03535) 715244..715537 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
QRF73_RS03540 (QRF73_03540) 715534..716019 + 486 WP_004889762.1 GNAT family N-acetyltransferase Toxin
QRF73_RS03545 (QRF73_03545) 716723..717315 + 593 Protein_697 hypothetical protein -
QRF73_RS03550 (QRF73_03550) 717412..717628 + 217 Protein_698 transposase -
QRF73_RS03560 (QRF73_03560) 718143..718856 - 714 WP_002916694.1 DUF554 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 717412..717564 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17585.56 Da        Isoelectric Point: 8.5144

>T284259 WP_004889762.1 NZ_CP127839:715534-716019 [Klebsiella pneumoniae RYC492]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPDPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDSMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT284259 WP_004150912.1 NZ_CP127839:715244-715537 [Klebsiella pneumoniae RYC492]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A447W563

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References