Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 2362544..2363131 Replicon chromosome
Accession NZ_CP127390
Organism Propionimicrobium sp. PCR01-08-3

Toxin (Protein)


Gene name graT Uniprot ID -
Locus tag QQ658_RS10880 Protein ID WP_286024872.1
Coordinates 2362544..2362825 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QQ658_RS10885 Protein ID WP_286024873.1
Coordinates 2362835..2363131 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQ658_RS10860 (QQ658_10860) 2358261..2359358 + 1098 WP_286024868.1 phosphate ABC transporter substrate-binding protein PstS -
QQ658_RS10865 (QQ658_10865) 2359488..2360486 + 999 WP_286024869.1 phosphate ABC transporter permease subunit PstC -
QQ658_RS10870 (QQ658_10870) 2360483..2361604 + 1122 WP_286024870.1 phosphate ABC transporter permease PstA -
QQ658_RS10875 (QQ658_10875) 2361690..2362469 + 780 WP_286024871.1 phosphate ABC transporter ATP-binding protein PstB -
QQ658_RS10880 (QQ658_10880) 2362544..2362825 + 282 WP_286024872.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QQ658_RS10885 (QQ658_10885) 2362835..2363131 + 297 WP_286024873.1 HigA family addiction module antitoxin Antitoxin
QQ658_RS10890 (QQ658_10890) 2363189..2363926 + 738 WP_286024874.1 glycerophosphodiester phosphodiesterase family protein -
QQ658_RS10895 (QQ658_10895) 2364040..2364696 + 657 WP_286024875.1 hypothetical protein -
QQ658_RS10900 (QQ658_10900) 2365075..2365611 + 537 WP_286024876.1 GNAT family N-acetyltransferase -
QQ658_RS10905 (QQ658_10905) 2365725..2365958 + 234 WP_286024877.1 toxin-antitoxin system -
QQ658_RS10910 (QQ658_10910) 2365955..2366374 + 420 WP_286024878.1 type II toxin-antitoxin system VapC family toxin -
QQ658_RS10915 (QQ658_10915) 2366483..2366614 + 132 WP_286024879.1 hypothetical protein -
QQ658_RS10920 (QQ658_10920) 2366696..2367832 - 1137 WP_286024880.1 YbfB/YjiJ family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(11-65)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10906.49 Da        Isoelectric Point: 9.1493

>T284238 WP_286024872.1 NZ_CP127390:2362544-2362825 [Propionimicrobium sp. PCR01-08-3]
VIRSFADKQTERLFMRETVRTLDPQIQRNALIKLWLLDAADTLQDLRIPPGNHLEALHGDRTGQHSIRINKKWRICFTWT
KAGPTEVEITDYH

Download         Length: 282 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11077.75 Da        Isoelectric Point: 6.8808

>AT284238 WP_286024873.1 NZ_CP127390:2362835-2363131 [Propionimicrobium sp. PCR01-08-3]
MTEKMAPVHPGEILQEEFMEPLGITQNRLAVSIGVPPRRINEIVHGKRRITADTALRLGRYFGTTAQIWLNLQTHHDLEL
AKDRAREEIDAITPLQAA

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References