Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1021195..1021865 Replicon chromosome
Accession NZ_CP127390
Organism Propionimicrobium sp. PCR01-08-3

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag QQ658_RS04775 Protein ID WP_286026525.1
Coordinates 1021195..1021545 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name HigA2 Uniprot ID -
Locus tag QQ658_RS04780 Protein ID WP_286027029.1
Coordinates 1021551..1021865 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QQ658_RS04750 (QQ658_04750) 1017237..1018580 + 1344 WP_286026520.1 MFS transporter -
QQ658_RS04755 (QQ658_04755) 1018577..1019551 + 975 WP_286026521.1 2-hydroxyacid dehydrogenase -
QQ658_RS04760 (QQ658_04760) 1019816..1020367 + 552 WP_286026522.1 hypothetical protein -
QQ658_RS04765 (QQ658_04765) 1020349..1020981 + 633 WP_286026523.1 RES family NAD+ phosphorylase -
QQ658_RS04770 (QQ658_04770) 1020978..1021157 - 180 WP_286026524.1 hypothetical protein -
QQ658_RS04775 (QQ658_04775) 1021195..1021545 + 351 WP_286026525.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
QQ658_RS04780 (QQ658_04780) 1021551..1021865 + 315 WP_286027029.1 helix-turn-helix transcriptional regulator Antitoxin
QQ658_RS04785 (QQ658_04785) 1022166..1023206 + 1041 WP_286026526.1 LacI family DNA-binding transcriptional regulator -
QQ658_RS04790 (QQ658_04790) 1023374..1024990 + 1617 WP_286026527.1 CoA-transferase -
QQ658_RS04795 (QQ658_04795) 1024990..1025817 + 828 WP_286026528.1 enoyl-CoA hydratase/isomerase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-87)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13181.13 Da        Isoelectric Point: 7.2064

>T284233 WP_286026525.1 NZ_CP127390:1021195-1021545 [Propionimicrobium sp. PCR01-08-3]
MWSVDVELIEVWLDSLDAGSRRQVMAAIELLRDLGPQLGRPLVDTVSAFRHKNMKELRPGSSGRSELRILFAFDPERSAI
MLIAGDKSGDWKRWYKKKIPEADGLFDDHLRGSKGE

Download         Length: 351 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11776.34 Da        Isoelectric Point: 5.7585

>AT284233 WP_286027029.1 NZ_CP127390:1021551-1021865 [Propionimicrobium sp. PCR01-08-3]
MALSYEEYLAKHPMTPAERTEIDAHKERMLAEVRAYRLRDLREQAGLTQAQLAERIGVGQRQVSKIESGDLDNAKIGTIR
RYLEAVGGELTVDYVFGDQRIQVA

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References