Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-DinJ
Location 30399..30915 Replicon plasmid unnamed1
Accession NZ_CP127381
Organism Aerococcus urinae strain UMB3669

Toxin (Protein)


Gene name yafQ Uniprot ID -
Locus tag DBT50_RS00140 Protein ID WP_111852482.1
Coordinates 30399..30671 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A0A109REE1
Locus tag DBT50_RS00145 Protein ID WP_060778044.1
Coordinates 30664..30915 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DBT50_RS00115 (DBT50_000115) 26090..26863 + 774 WP_224785074.1 iron export ABC transporter permease subunit FetB -
DBT50_RS00120 (DBT50_000120) 26877..27656 + 780 WP_111852479.1 iron export ABC transporter permease subunit FetB -
DBT50_RS00125 (DBT50_000125) 27790..28242 + 453 WP_111852480.1 50S ribosomal protein L9 -
DBT50_RS00130 (DBT50_000130) 28392..29765 + 1374 WP_111852481.1 replicative DNA helicase -
DBT50_RS00140 (DBT50_000140) 30399..30671 - 273 WP_111852482.1 type II toxin-antitoxin system YafQ family toxin Toxin
DBT50_RS00145 (DBT50_000145) 30664..30915 - 252 WP_060778044.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
DBT50_RS00150 (DBT50_000150) 31025..31282 - 258 WP_285935973.1 hypothetical protein -
DBT50_RS00155 (DBT50_000155) 31300..31467 - 168 WP_111852485.1 histidine kinase -
DBT50_RS00160 (DBT50_000160) 31484..31663 - 180 WP_111852486.1 histidine kinase -
DBT50_RS00165 (DBT50_000165) 31693..31953 - 261 WP_111853457.1 hypothetical protein -
DBT50_RS00170 (DBT50_000170) 32725..33876 + 1152 WP_111852488.1 lactaldehyde reductase -
DBT50_RS00175 (DBT50_000175) 34256..34687 - 432 WP_111852489.1 YrhK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - tufA / hasC 1..591691 591691


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-81)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10783.59 Da        Isoelectric Point: 10.0983

>T284217 WP_111852482.1 NZ_CP127381:c30671-30399 [Aerococcus urinae]
MNKIRFTSAFKRDYKRYKKKHYPMTKIDKAIRLIASEEIEILINQYKLHNLKGEWQGYKELHVDGDTLIIYIDQKGIVTL
TRLGTHDQLF

Download         Length: 273 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9419.56 Da        Isoelectric Point: 4.2803

>AT284217 WP_060778044.1 NZ_CP127381:c30915-30664 [Aerococcus urinae]
MARINIRVDDDLKEQAKATFEDMGLDLTTAITLFIKYSVNSGELPFKPATKKQIENRQARAEAESDQLKTYDNVDDLLEA
LNE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A109REE1

References