Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ldrD-rdlD/Ldr(toxin)
Location 350455..350676 Replicon chromosome
Accession NZ_CP127316
Organism Escherichia coli strain Ch1

Toxin (Protein)


Gene name ldrD Uniprot ID A0A229AEQ8
Locus tag QRM71_RS01775 Protein ID WP_000176713.1
Coordinates 350455..350562 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name rdlD
Locus tag -
Coordinates 350610..350676 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRM71_RS01745 (345589) 345589..346671 + 1083 WP_000804726.1 peptide chain release factor 1 -
QRM71_RS01750 (346671) 346671..347504 + 834 WP_000456570.1 peptide chain release factor N(5)-glutamine methyltransferase -
QRM71_RS01755 (347501) 347501..347893 + 393 WP_000200377.1 invasion regulator SirB2 -
QRM71_RS01760 (347897) 347897..348706 + 810 WP_001257044.1 invasion regulator SirB1 -
QRM71_RS01765 (348742) 348742..349596 + 855 WP_000811065.1 3-deoxy-8-phosphooctulonate synthase -
QRM71_RS01770 (349791) 349791..350249 + 459 WP_000526135.1 IS200/IS605-like element IS200C family transposase -
QRM71_RS01775 (350455) 350455..350562 - 108 WP_000176713.1 type I toxin-antitoxin system toxin Ldr family protein Toxin
- (350612) 350612..350675 + 64 NuclAT_38 - -
- (350612) 350612..350675 + 64 NuclAT_38 - -
- (350612) 350612..350675 + 64 NuclAT_38 - -
- (350612) 350612..350675 + 64 NuclAT_38 - -
- (350612) 350612..350675 + 64 NuclAT_40 - -
- (350612) 350612..350675 + 64 NuclAT_40 - -
- (350612) 350612..350675 + 64 NuclAT_40 - -
- (350612) 350612..350675 + 64 NuclAT_40 - -
- (350612) 350612..350675 + 64 NuclAT_42 - -
- (350612) 350612..350675 + 64 NuclAT_42 - -
- (350612) 350612..350675 + 64 NuclAT_42 - -
- (350612) 350612..350675 + 64 NuclAT_42 - -
- (350610) 350610..350676 + 67 NuclAT_16 - Antitoxin
- (350610) 350610..350676 + 67 NuclAT_16 - Antitoxin
- (350610) 350610..350676 + 67 NuclAT_16 - Antitoxin
- (350610) 350610..350676 + 67 NuclAT_16 - Antitoxin
- (350610) 350610..350676 + 67 NuclAT_20 - Antitoxin
- (350610) 350610..350676 + 67 NuclAT_20 - Antitoxin
- (350610) 350610..350676 + 67 NuclAT_20 - Antitoxin
- (350610) 350610..350676 + 67 NuclAT_20 - Antitoxin
- (350610) 350610..350676 + 67 NuclAT_24 - Antitoxin
- (350610) 350610..350676 + 67 NuclAT_24 - Antitoxin
- (350610) 350610..350676 + 67 NuclAT_24 - Antitoxin
- (350610) 350610..350676 + 67 NuclAT_24 - Antitoxin
- (350610) 350610..350676 + 67 NuclAT_28 - Antitoxin
- (350610) 350610..350676 + 67 NuclAT_28 - Antitoxin
- (350610) 350610..350676 + 67 NuclAT_28 - Antitoxin
- (350610) 350610..350676 + 67 NuclAT_28 - Antitoxin
- (350610) 350610..350676 + 67 NuclAT_30 - Antitoxin
- (350610) 350610..350676 + 67 NuclAT_30 - Antitoxin
- (350610) 350610..350676 + 67 NuclAT_30 - Antitoxin
- (350610) 350610..350676 + 67 NuclAT_30 - Antitoxin
- (350610) 350610..350676 + 67 NuclAT_34 - Antitoxin
- (350610) 350610..350676 + 67 NuclAT_34 - Antitoxin
- (350610) 350610..350676 + 67 NuclAT_34 - Antitoxin
- (350610) 350610..350676 + 67 NuclAT_34 - Antitoxin
QRM71_RS01780 (350990) 350990..351097 - 108 WP_000170955.1 type I toxin-antitoxin system toxin Ldr family protein -
- (351150) 351150..351211 + 62 NuclAT_37 - -
- (351150) 351150..351211 + 62 NuclAT_37 - -
- (351150) 351150..351211 + 62 NuclAT_37 - -
- (351150) 351150..351211 + 62 NuclAT_37 - -
- (351150) 351150..351211 + 62 NuclAT_39 - -
- (351150) 351150..351211 + 62 NuclAT_39 - -
- (351150) 351150..351211 + 62 NuclAT_39 - -
- (351150) 351150..351211 + 62 NuclAT_39 - -
- (351150) 351150..351211 + 62 NuclAT_41 - -
- (351150) 351150..351211 + 62 NuclAT_41 - -
- (351150) 351150..351211 + 62 NuclAT_41 - -
- (351150) 351150..351211 + 62 NuclAT_41 - -
- (351150) 351150..351212 + 63 NuclAT_17 - -
- (351150) 351150..351212 + 63 NuclAT_17 - -
- (351150) 351150..351212 + 63 NuclAT_17 - -
- (351150) 351150..351212 + 63 NuclAT_17 - -
- (351150) 351150..351212 + 63 NuclAT_21 - -
- (351150) 351150..351212 + 63 NuclAT_21 - -
- (351150) 351150..351212 + 63 NuclAT_21 - -
- (351150) 351150..351212 + 63 NuclAT_21 - -
- (351150) 351150..351212 + 63 NuclAT_25 - -
- (351150) 351150..351212 + 63 NuclAT_25 - -
- (351150) 351150..351212 + 63 NuclAT_25 - -
- (351150) 351150..351212 + 63 NuclAT_25 - -
- (351150) 351150..351212 + 63 NuclAT_29 - -
- (351150) 351150..351212 + 63 NuclAT_29 - -
- (351150) 351150..351212 + 63 NuclAT_29 - -
- (351150) 351150..351212 + 63 NuclAT_29 - -
- (351150) 351150..351212 + 63 NuclAT_31 - -
- (351150) 351150..351212 + 63 NuclAT_31 - -
- (351150) 351150..351212 + 63 NuclAT_31 - -
- (351150) 351150..351212 + 63 NuclAT_31 - -
- (351150) 351150..351212 + 63 NuclAT_35 - -
- (351150) 351150..351212 + 63 NuclAT_35 - -
- (351150) 351150..351212 + 63 NuclAT_35 - -
- (351150) 351150..351212 + 63 NuclAT_35 - -
QRM71_RS01785 (351503) 351503..352603 - 1101 WP_001309461.1 sodium-potassium/proton antiporter ChaA -
QRM71_RS01790 (352873) 352873..353103 + 231 WP_001146450.1 putative cation transport regulator ChaB -
QRM71_RS01795 (353261) 353261..353956 + 696 WP_001336325.1 glutathione-specific gamma-glutamylcyclotransferase -
QRM71_RS01800 (354000) 354000..354353 - 354 WP_001169669.1 DsrE/F sulfur relay family protein YchN -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 349791..350249 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4031.79 Da        Isoelectric Point: 11.4779

>T284163 WP_000176713.1 NZ_CP127316:c350562-350455 [Escherichia coli]
MTLTQFAMTFWHDLAAPILAGIITAAIVSWWRNRK

Download         Length: 108 bp

Antitoxin


Download         Length: 67 bp

>AT284163 NZ_CP127316:350610-350676 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTATACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A229AEQ8

Antitoxin

Download structure file

References