Detailed information of TA system TA028416

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/MqsR-MqsA
• Location: 1470550..1471205
• Replicon: chromosome
• Accession: NC_018829
• Organism: Bordetella bronchiseptica MO149

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: BN115_RS06905
• Protein ID: WP_049806323.1
• Coordinates: 1470550..1470801 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: Q7VY40
• Locus tag: BN115_RS06910
• Protein ID: WP_003809516.1
• Coordinates: 1470804..1471205 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BN115_RS06880	1465710..1466840	-	1131	WP_004568222.1	helix-turn-helix transcriptional regulator	-
BN115_RS06885	1467075..1467617	+	543	WP_004568221.1	MOSC domain-containing protein	-
BN115_RS06890	1467793..1468857	+	1065	WP_003819826.1	fructose-bisphosphate aldolase class II	-
BN115_RS06895	1468942..1469388	-	447	WP_003819827.1	GFA family protein	-
BN115_RS06900	1469614..1470495	+	882	WP_003809513.1	phosphoribosylaminoimidazolesuccinocarboxamide synthase	-
BN115_RS06905	1470550..1470801	+	252	WP_049806323.1	type II toxin-antitoxin system MqsR family toxin	Toxin
BN115_RS06910	1470804..1471205	+	402	WP_003809516.1	type II toxin-antitoxin system MqsA family antitoxin	Antitoxin
BN115_RS23855	1471225..1471461	+	237	WP_003819834.1	hypothetical protein	-
BN115_RS06915	1471469..1471948	+	480	WP_003819836.1	disulfide bond formation protein B	-
BN115_RS06920	1472097..1472612	+	516	WP_019247930.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
BN115_RS06925	1472615..1473805	+	1191	WP_015041223.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
BN115_RS06930	1473825..1474862	+	1038	WP_003819838.1	threonylcarbamoyl-AMP synthase	-
BN115_RS06935	1474999..1476021	+	1023	WP_003809532.1	amino acid ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (10-82)

Antitoxin

• Antitoxin MqsA/HigA-2 (1-131)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 8940.46 Da
• Isoelectric Point: 9.7242

>T28416 WP_049806323.1 NC_018829:1470550-1470801 [Bordetella bronchiseptica MO149]
IGGAATKKPGQKRRAGAAALGLDFSAMVETVLALTPRDFHKSMTTHADHRIWQDVYCPVTAMGAVYLKLTVLDGVPIVSF
KEL

Nucleotide

• Length: 252 bp

>T28416 NC_018829:1470550-1470801 [Bordetella bronchiseptica MO149]
ATTGGAGGCGCGGCGACAAAAAAGCCGGGACAAAAGCGTCGCGCCGGGGCGGCGGCGCTGGGGCTGGATTTCAGCGCCAT
GGTCGAAACCGTGCTTGCATTGACACCGCGGGATTTCCACAAAAGCATGACTACCCATGCCGACCATCGGATTTGGCAGG
ACGTCTATTGCCCGGTGACAGCGATGGGCGCCGTCTACCTGAAGCTGACGGTCCTCGACGGCGTGCCGATCGTGTCGTTC
AAGGAGTTGTGA

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14528.70 Da
• Isoelectric Point: 8.5005

>AT28416 WP_003809516.1 NC_018829:1470804-1471205 [Bordetella bronchiseptica MO149]
MKCPVCGAAALARDTRDVPYSYKGETITIAAVTGDWCPACGENVLDGAESARVSEAMLAFNRLVNARRVDPGFIVRVRRK
LGLDQREAAALFGGGTNAFSRYENGKTRPPLALVKLLRLLDRHPELLEEVRAD

Nucleotide

• Length: 402 bp

>AT28416 NC_018829:1470804-1471205 [Bordetella bronchiseptica MO149]
ATGAAGTGTCCCGTATGCGGAGCGGCCGCGCTGGCGCGTGATACTCGCGATGTGCCCTATAGCTACAAGGGCGAGACCAT
CACGATTGCGGCGGTGACGGGCGACTGGTGTCCGGCATGCGGCGAGAACGTGCTCGATGGCGCCGAATCGGCGCGGGTGA
GCGAGGCCATGCTGGCTTTCAACCGCCTGGTCAACGCCCGCCGCGTCGACCCCGGGTTCATCGTGCGGGTGCGCAGGAAG
CTGGGGCTGGACCAGCGCGAAGCCGCGGCGCTGTTCGGCGGCGGCACCAATGCGTTCTCGCGTTACGAGAACGGCAAGAC
GCGCCCGCCGCTGGCGCTGGTGAAGCTGCTCAGGCTGCTGGATCGCCATCCGGAGCTGCTGGAGGAAGTCCGTGCGGATT
GA

Structures

Antitoxin

• AlphaFold DB: A0A0H3LKS6