Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 4677604..4677862 Replicon chromosome
Accession NZ_CP127314
Organism Escherichia coli strain C25

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag QRM69_RS22655 Protein ID WP_000809168.1
Coordinates 4677710..4677862 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 4677604..4677661 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRM69_RS22640 4673434..4674693 - 1260 WP_000494928.1 hypothetical protein -
QRM69_RS22645 4674822..4676315 - 1494 WP_001443162.1 sulfatase-like hydrolase/transferase -
QRM69_RS22650 4676335..4677096 - 762 WP_001274832.1 outer membrane protein OmpK -
- 4677604..4677661 - 58 - - Antitoxin
QRM69_RS22655 4677710..4677862 + 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
QRM69_RS22660 4677967..4679097 - 1131 WP_001118465.1 molecular chaperone DnaJ -
QRM69_RS22665 4679186..4681102 - 1917 WP_000516135.1 molecular chaperone DnaK -
QRM69_RS22670 4681474..4681878 + 405 WP_000843687.1 DUF2541 family protein -
QRM69_RS22675 4681904..4682617 + 714 WP_001102391.1 acidic protein MsyB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T284156 WP_000809168.1 NZ_CP127314:4677710-4677862 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

Antitoxin


Download         Length: 58 bp

>AT284156 NZ_CP127314:c4677661-4677604 [Escherichia coli]
GTTCTGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References