Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | ralRA/- |
| Location | 2620281..2620652 | Replicon | chromosome |
| Accession | NZ_CP127314 | ||
| Organism | Escherichia coli strain C25 | ||
Toxin (Protein)
| Gene name | ralR | Uniprot ID | Q8Z5Y6 |
| Locus tag | QRM69_RS12390 | Protein ID | WP_010989194.1 |
| Coordinates | 2620458..2620652 (-) | Length | 65 a.a. |
Antitoxin (RNA)
| Gene name | ralA | ||
| Locus tag | - | ||
| Coordinates | 2620281..2620459 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QRM69_RS12350 (2615723) | 2615723..2616379 | - | 657 | WP_000011644.1 | carbon-nitrogen hydrolase family protein YobB | - |
| QRM69_RS12355 (2616482) | 2616482..2616712 | - | 231 | WP_000916763.1 | DNA polymerase III subunit theta | - |
| QRM69_RS12360 (2616851) | 2616851..2617225 | + | 375 | WP_000168747.1 | CopC domain-containing protein YobA | - |
| QRM69_RS12365 (2617229) | 2617229..2618101 | + | 873 | WP_000879311.1 | copper homeostasis membrane protein CopD | - |
| QRM69_RS12370 (2618114) | 2618114..2618455 | + | 342 | WP_000984819.1 | YebY family protein | - |
| QRM69_RS12375 (2618847) | 2618847..2619923 | - | 1077 | WP_286005063.1 | phage integrase Arm DNA-binding domain-containing protein | - |
| QRM69_RS12380 (2619889) | 2619889..2620170 | - | 282 | WP_001311878.1 | excisionase | - |
| - (2620281) | 2620281..2620459 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (2620281) | 2620281..2620459 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (2620281) | 2620281..2620459 | + | 179 | NuclAT_0 | - | Antitoxin |
| - (2620281) | 2620281..2620459 | + | 179 | NuclAT_0 | - | Antitoxin |
| QRM69_RS12385 (2620277) | 2620277..2620465 | - | 189 | WP_024165285.1 | DUF1187 family protein | - |
| QRM69_RS12390 (2620458) | 2620458..2620652 | - | 195 | WP_010989194.1 | type I toxin-antitoxin system endodeoxyribonuclease toxin RalR | Toxin |
| QRM69_RS12395 (2620716) | 2620716..2621768 | - | 1053 | WP_021517972.1 | RecT family recombinase | - |
| QRM69_RS12400 (2621780) | 2621780..2624866 | - | 3087 | WP_286005064.1 | exodeoxyribonuclease VIII | - |
| QRM69_RS12405 (2624891) | 2624891..2625187 | - | 297 | WP_032284335.1 | hypothetical protein | - |
| QRM69_RS12410 (2625262) | 2625262..2625432 | - | 171 | WP_097735238.1 | YdaE family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2612980..2663693 | 50713 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 65 a.a. Molecular weight: 7077.01 Da Isoelectric Point: 9.2886
>T284147 WP_010989194.1 NZ_CP127314:c2620652-2620458 [Escherichia coli]
MRYEKVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYSGSEKEALERWNKRTTGNNNGGVHV
MRYEKVKPCPFCGCPSVTVKAISGYYRAKCNGCESRTGYSGSEKEALERWNKRTTGNNNGGVHV
Download Length: 195 bp
Antitoxin
Download Length: 179 bp
>AT284147 NZ_CP127314:2620281-2620459 [Escherichia coli]
GAGGACAGAAGCTTCTCGCAATTAAAATTTATCAGCTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTGGTTAATTTTGTTTTTGAGTACCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCAGTAATTTT
GAGGACAGAAGCTTCTCGCAATTAAAATTTATCAGCTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTGGTTAATTTTGTTTTTGAGTACCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCAGTAATTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
