Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 980199..980998 Replicon chromosome
Accession NZ_CP127314
Organism Escherichia coli strain C25

Toxin (Protein)


Gene name yhaV Uniprot ID Q8FDB4
Locus tag QRM69_RS04730 Protein ID WP_000347252.1
Coordinates 980199..980663 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag QRM69_RS04735 Protein ID WP_001296435.1
Coordinates 980663..980998 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRM69_RS04700 (975200) 975200..975634 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
QRM69_RS04705 (975652) 975652..976530 - 879 WP_001298314.1 PTS N-acetylgalactosamine transporter subunit IID -
QRM69_RS04710 (976520) 976520..977299 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
QRM69_RS04715 (977310) 977310..977783 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
QRM69_RS04720 (977806) 977806..979086 - 1281 WP_000681926.1 tagatose-bisphosphate aldolase subunit KbaZ -
QRM69_RS04725 (979335) 979335..980144 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QRM69_RS04730 (980199) 980199..980663 - 465 WP_000347252.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QRM69_RS04735 (980663) 980663..980998 - 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QRM69_RS04740 (981147) 981147..982718 - 1572 WP_001273940.1 galactarate dehydratase -
QRM69_RS04745 (983093) 983093..984427 + 1335 WP_000979025.1 galactarate/glucarate/glycerate transporter GarP -
QRM69_RS04750 (984443) 984443..985213 + 771 WP_001058223.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17750.11 Da        Isoelectric Point: 9.4947

>T284137 WP_000347252.1 NZ_CP127314:c980663-980199 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEESH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT284137 WP_001296435.1 NZ_CP127314:c980998-980663 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q8FDB4

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References