Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 141951..142553 Replicon chromosome
Accession NZ_CP127314
Organism Escherichia coli strain C25

Toxin (Protein)


Gene name higB Uniprot ID S1P416
Locus tag QRM69_RS00640 Protein ID WP_000897302.1
Coordinates 142242..142553 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QRM69_RS00635 Protein ID WP_000356397.1
Coordinates 141951..142241 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRM69_RS00610 (138024) 138024..138926 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
QRM69_RS00615 (138923) 138923..139558 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
QRM69_RS00620 (139555) 139555..140484 + 930 WP_000027720.1 formate dehydrogenase accessory protein FdhE -
QRM69_RS00625 (140700) 140700..140918 - 219 WP_001314326.1 CopG family transcriptional regulator -
QRM69_RS00630 (141314) 141314..141592 - 279 WP_001296612.1 hypothetical protein -
QRM69_RS00635 (141951) 141951..142241 - 291 WP_000356397.1 NadS family protein Antitoxin
QRM69_RS00640 (142242) 142242..142553 - 312 WP_000897302.1 hypothetical protein Toxin
QRM69_RS00645 (142783) 142783..143691 + 909 WP_001305059.1 alpha/beta hydrolase -
QRM69_RS00650 (143755) 143755..144696 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
QRM69_RS00655 (144741) 144741..145178 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
QRM69_RS00660 (145175) 145175..146047 - 873 WP_000920762.1 virulence factor BrkB family protein -
QRM69_RS00665 (146041) 146041..146640 - 600 WP_001443191.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12203.19 Da        Isoelectric Point: 9.7791

>T284136 WP_000897302.1 NZ_CP127314:c142553-142242 [Escherichia coli]
MLFIETEIFTEDVQKLLNDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT284136 WP_000356397.1 NZ_CP127314:c142241-141951 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P416

Antitoxin

Source ID Structure

References