284119

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 3390935..3391437 Replicon chromosome
Accession NZ_CP127306
Organism Escherichia coli strain C51

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag QRM70_RS16455 Protein ID WP_000767829.1
Coordinates 3391183..3391437 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag QRM70_RS16450 Protein ID WP_001259255.1
Coordinates 3390935..3391186 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRM70_RS16425 (3386112) 3386112..3387179 - 1068 WP_000080055.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
QRM70_RS16430 (3387179) 3387179..3388249 - 1071 WP_000108933.1 histidinol-phosphate transaminase -
QRM70_RS16435 (3388246) 3388246..3389550 - 1305 WP_001352244.1 histidinol dehydrogenase -
QRM70_RS16440 (3389556) 3389556..3390455 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
QRM70_RS16445 (3390601) 3390601..3390651 - 51 WP_001364200.1 his operon leader peptide -
QRM70_RS16450 (3390935) 3390935..3391186 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
QRM70_RS16455 (3391183) 3391183..3391437 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
QRM70_RS16460 (3391520) 3391520..3392344 + 825 WP_000754737.1 SDR family oxidoreductase -
QRM70_RS16465 (3392390) 3392390..3393319 + 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
QRM70_RS16470 (3393533) 3393533..3393595 + 63 WP_010723108.1 membrane protein YoeI -
QRM70_RS16475 (3393585) 3393585..3394943 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
QRM70_RS16480 (3395122) 3395122..3396180 + 1059 WP_000492346.1 thiosulfate utilization transporter TsuA/YeeE -
QRM70_RS16485 (3396194) 3396194..3396421 + 228 WP_000985272.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T284119 WP_000767829.1 NZ_CP127306:3391183-3391437 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT284119 WP_001259255.1 NZ_CP127306:3390935-3391186 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References