Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 2055427..2056226 Replicon chromosome
Accession NZ_CP127306
Organism Escherichia coli strain C51

Toxin (Protein)


Gene name yhaV Uniprot ID F4VJD3
Locus tag QRM70_RS09975 Protein ID WP_000347266.1
Coordinates 2055427..2055891 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag QRM70_RS09980 Protein ID WP_001307405.1
Coordinates 2055891..2056226 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRM70_RS09945 (2050428) 2050428..2050862 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
QRM70_RS09950 (2050880) 2050880..2051758 - 879 WP_001315856.1 PTS N-acetylgalactosamine transporter subunit IID -
QRM70_RS09955 (2051748) 2051748..2052527 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
QRM70_RS09960 (2052538) 2052538..2053011 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
QRM70_RS09965 (2053034) 2053034..2054314 - 1281 WP_000681921.1 tagatose-bisphosphate aldolase subunit KbaZ -
QRM70_RS09970 (2054563) 2054563..2055372 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
QRM70_RS09975 (2055427) 2055427..2055891 - 465 WP_000347266.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
QRM70_RS09980 (2055891) 2055891..2056226 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
QRM70_RS09985 (2056375) 2056375..2057946 - 1572 WP_001273741.1 galactarate dehydratase -
QRM70_RS09990 (2058321) 2058321..2059652 + 1332 WP_175099495.1 galactarate/glucarate/glycerate transporter GarP -
QRM70_RS09995 (2059668) 2059668..2060438 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17841.18 Da        Isoelectric Point: 9.4947

>T284113 WP_000347266.1 NZ_CP127306:c2055891-2055427 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRFFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT284113 WP_001307405.1 NZ_CP127306:c2056226-2055891 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A836NGD2

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References