Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 1242610..1243212 Replicon chromosome
Accession NZ_CP127306
Organism Escherichia coli strain C51

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag QRM70_RS06010 Protein ID WP_000897305.1
Coordinates 1242901..1243212 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag QRM70_RS06005 Protein ID WP_000356397.1
Coordinates 1242610..1242900 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QRM70_RS05975 (1238535) 1238535..1239437 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
QRM70_RS05980 (1239434) 1239434..1240069 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
QRM70_RS05985 (1240066) 1240066..1240995 + 930 WP_000027708.1 formate dehydrogenase accessory protein FdhE -
QRM70_RS05990 (1241325) 1241325..1241567 - 243 WP_001087409.1 protein YiiF -
QRM70_RS05995 (1241787) 1241787..1242005 - 219 WP_001315930.1 CopG family transcriptional regulator -
QRM70_RS06000 (1242336) 1242336..1242524 - 189 WP_285965550.1 hypothetical protein -
QRM70_RS06005 (1242610) 1242610..1242900 - 291 WP_000356397.1 NadS family protein Antitoxin
QRM70_RS06010 (1242901) 1242901..1243212 - 312 WP_000897305.1 hypothetical protein Toxin
QRM70_RS06015 (1243441) 1243441..1244349 + 909 WP_001162704.1 alpha/beta hydrolase -
QRM70_RS06020 (1244413) 1244413..1245354 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
QRM70_RS06025 (1245399) 1245399..1245836 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
QRM70_RS06030 (1245833) 1245833..1246705 - 873 WP_285965551.1 virulence factor BrkB family protein -
QRM70_RS06035 (1246699) 1246699..1247298 - 600 WP_001295269.1 glucose-1-phosphatase -
QRM70_RS06040 (1247397) 1247397..1248182 - 786 WP_000059678.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T284110 WP_000897305.1 NZ_CP127306:c1243212-1242901 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT284110 WP_000356397.1 NZ_CP127306:c1242900-1242610 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References